Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles

Kin Man Au; Sayed Nabeel Hyder; Kyle Wagner; Caihong Shi; Young Seok Kim; Joseph M Caster; Xi Tian; Yuanzeng Min; Andrew Z Wang

doi:10.1002/smll.201501902

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Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles

Journal article

Peer reviewed

Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles

Kin Man Au, Sayed Nabeel Hyder, Kyle Wagner, Caihong Shi, Young Seok Kim, Joseph M Caster, Xi Tian, Yuanzeng Min and Andrew Z Wang

Small (Weinheim an der Bergstrasse, Germany), Vol.11(48), pp.6404-6410

12/22/2015

DOI: 10.1002/smll.201501902

PMCID: PMC4813349

PMID: 26577747

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Abstract

Collagen IV-targeting peptide-conjugated basement membrane-targeting nanoparticles are successfully engineered to identify early-stage blood vessel injury induced by high-dose radiotherapy.

Fluorescence

Optical Imaging

Lactic Acid - chemistry

Basement Membrane - drug effects

Nanoparticles - chemistry

Polylactic Acid-Polyglycolic Acid Copolymer

Vascular System Injuries - diagnosis

Radiation Injuries - diagnosis

Polyethylene Glycols - chemistry

Radiotherapy - adverse effects

Basement Membrane - metabolism

Animals

Collagen Type IV - pharmacology

Mice, Nude

Polyglycolic Acid - chemistry

Dose-Response Relationship, Radiation

Details

Title: Subtitle: Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles
Creators: Kin Man Au - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Sayed Nabeel Hyder - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Kyle Wagner - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Caihong Shi - School of Transnational Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe, Shenyang, Liaoning, 110016, China
Young Seok Kim - Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 138-736, South Korea
Joseph M Caster - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Xi Tian - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Yuanzeng Min - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Andrew Z Wang - Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Resource Type: Journal article
Publication Details: Small (Weinheim an der Bergstrasse, Germany), Vol.11(48), pp.6404-6410
DOI: 10.1002/smll.201501902
PMID: 26577747
PMCID: PMC4813349
NLM abbreviation: Small
ISSN: 1613-6810
eISSN: 1613-6829
Publisher: Germany
Grant note: U54 CA198999 / NCI NIH HHS R01CA178748 / NCI NIH HHS U54 CA151652 / NCI NIH HHS P30 CA016086 / NCI NIH HHS U54-CA151652 / NCI NIH HHS R01 CA178748 / NCI NIH HHS
Language: English
Date published: 12/22/2015
Academic Unit: Radiation Oncology
Record Identifier: 9984047605502771

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