Journal article
Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior
Neuron (Cambridge, Mass.), Vol.89(4), pp.857-866
02/17/2016
DOI: 10.1016/j.neuron.2016.01.011
PMCID: PMC4760847
PMID: 26853301
Abstract
The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of each individual element of the circuit is unclear. The projection from the vHPC to the mPFC has been implicated in anxiety-related neural synchrony and spatial representations of aversion. The role of this projection was examined using multi-site neural recordings combined with optogenetic terminal inhibition. Inhibition of vHPC input to the mPFC disrupted anxiety and mPFC representations of aversion, and reduced theta synchrony in a pathway-, frequency-and task-specific manner. Moreover, bilateral, but not unilateral, inhibition altered physiological correlates of anxiety in the BLA, mimicking a safety-like state. These results reveal a specific role for the vHPC-mPFC projection in anxiety-related behavior and the spatial representation of aversive information within the mPFC.
Details
- Title: Subtitle
- Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior
- Creators
- Nancy Padilla-Coreano - Columbia UniversityScott S. Bolkan - Columbia UniversityGeorgia M. Pierce - Columbia UniversityDakota R. Blackman - Barnard CollegeWilliam D. Hardin - Columbia UniversityAlvaro L. Garcia-Garcia - Columbia UniversityTimothy J. Spellman - Columbia UniversityJoshua A. Gordon - Columbia University
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.89(4), pp.857-866
- DOI
- 10.1016/j.neuron.2016.01.011
- PMID
- 26853301
- PMCID
- PMC4760847
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Jerome Jacobson Foundation Sackler Institute Award National Science Foundation; National Science Foundation (NSF) NIH F31MH102041 / NRSA from NIMH Hope for Depression Research Foundation Spanish Ministry of Science; Spanish Government International Mental Health Research Organization MH081968; MH096274 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 02/17/2016
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984944741702771
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