Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

Jie Ting; Leslie Wilson; Sarah Jane Schwarzenberg; Ryan Himes; Bradley Barth; Melena D Bellin; Peter R Durie; Douglas S Fishman; Steven D Freedman; Cheryl E Gariepy; Matthew J Giefer; Tanja Gonska; Sohail Z Husain; Soma Kumar; Veronique D Morinville; Mark E Lowe; Chee Y Ooi; John F Pohl; David Troendle; Danielle Usatin; Steven L Werlin; Michael Wilschanski; Melvin B Heyman; Aliye Uc

doi:10.1097/MPG.0000000000001057

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Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

Journal article

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Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

Jie Ting, Leslie Wilson, Sarah Jane Schwarzenberg, Ryan Himes, Bradley Barth, Melena D Bellin, Peter R Durie, Douglas S Fishman, Steven D Freedman, Cheryl E Gariepy, …

Journal of pediatric gastroenterology and nutrition, Vol.62(3), pp.443-449

03/2016

DOI: 10.1097/MPG.0000000000001057

PMCID: PMC4767646

PMID: 26704866

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Abstract

Objective: To estimate selected direct medical care costs of children with chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP). Methods: We performed a cross-sectional study of data from International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE), a multinational registry of children with ARP or CP. We determined health care utilization and estimated costs of hospitalizations, surgical and endoscopic procedures, and medications in our study population. Health care utilization data were obtained from all subjects enrolled in the study, and costs were calculated using national United States costs. Results: We included 224 subjects (median age 12.7 years), 42% of whom had CP. Mean number of hospitalizations, including for surgery and endoscopic retrograde cholangiopancreatography, was 2.3 per person per year, costing an estimated average $38,755 per person per year. Including outpatient medications, estimated total mean cost was $40,589 per person per year. Subjects using surgical procedures or endoscopic retrograde cholangiopancreatography incurred mean annual costs of $42,951 per person and $12,035 per person, respectively. Estimated annual costs of pancreatic enzyme replacement therapy, diabetic medications, and pain medications were $4114, $1761, and $614 per person, respectively. In an exploratory analysis, patients with the following characteristics appear to accrue higher costs than those without them: more frequent ARP attacks per year, reported constant or episodic pain, family history of pancreatic cancer, and use of pain medication. Conclusions: ARP and CP are uncommon childhood conditions. The severe burden of disease associated with these conditions and their chronicity results in high health care utilization and costs. Interventions that reduce the need for hospitalization could lower costs for these children and their families.

Pain

Quality of Life

hospitalization

healthcare costs

economic

Details

Title: Subtitle: Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry
Creators: Jie Ting - University of California at San Francisco, San Francisco, CA, USA
Leslie Wilson - University of California at San Francisco, San Francisco, CA, USA
Sarah Jane Schwarzenberg - University of Minnesota Masonic Children’s Hospital, Minneapolis, Minnesota, USA
Ryan Himes - Baylor College of Medicine, Houston, TX, USA
Bradley Barth - University of Texas Southwestern Medical School, Dallas, TX, USA
Melena D Bellin - University of Minnesota Masonic Children’s Hospital, Minneapolis, Minnesota, USA
Peter R Durie - Hospital for Sick Children, Toronto, ON, Canada
Douglas S Fishman - Baylor College of Medicine, Houston, TX, USA
Steven D Freedman - Harvard Medical School, Boston, MA, USA
Cheryl E Gariepy - Nationwide Children’s Hospital, Columbus, OH, USA
Matthew J Giefer - Seattle Children’s Hospital, Seattle, WA, USA
Tanja Gonska - Hospital for Sick Children, Toronto, ON, Canada
Sohail Z Husain - Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
Soma Kumar - Nationwide Children’s Hospital, Columbus, OH, USA
Veronique D Morinville - Montreal Children’s Hospital, McGill University, Montreal, QC, Canada
Mark E Lowe - Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
Chee Y Ooi - Discipline of Paediatrics, School of Women’s and Children’s Health, Medicine, University of New South Wales and Sydney Children’s Hospital Randwick, Sydney, Australia
John F Pohl - University of Utah, Salt Lake City, UT, USA
David Troendle - University of Texas Southwestern Medical School, Dallas, TX, USA
Danielle Usatin - University of California at San Francisco, San Francisco, CA, USA
Steven L Werlin - Medical College of Wisconsin, Milwaukee, WI, USA
Michael Wilschanski - Hadassah Hebrew University Hospital, Jerusalem, Israel
Melvin B Heyman - University of California at San Francisco, San Francisco, CA, USA
Aliye Uc - University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.62(3), pp.443-449
DOI: 10.1097/MPG.0000000000001057
PMID: 26704866
PMCID: PMC4767646
NLM abbreviation: J Pediatr Gastroenterol Nutr
ISSN: 0277-2116
eISSN: 1536-4801
Language: English
Date published: 03/2016
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984047899402771

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