Direct electrophysiological mapping of human pitch-related processing in auditory cortex

Phillip E Gander; Sukhbinder Kumar; William Sedley; Kirill V Nourski; Hiroyuki Oya; Christopher K Kovach; Hiroto Kawasaki; Yukiko Kikuchi; Roy D Patterson; Matthew A Howard; Timothy D Griffiths

doi:10.1016/j.neuroimage.2019.116076

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Direct electrophysiological mapping of human pitch-related processing in auditory cortex

Journal article

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Direct electrophysiological mapping of human pitch-related processing in auditory cortex

Phillip E Gander, Sukhbinder Kumar, William Sedley, Kirill V Nourski, Hiroyuki Oya, Christopher K Kovach, Hiroto Kawasaki, Yukiko Kikuchi, Roy D Patterson, Matthew A Howard, …

NeuroImage (Orlando, Fla.), Vol.202, pp.116076-116076

11/15/2019

DOI: 10.1016/j.neuroimage.2019.116076

PMID: 31401239

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https://www.ncbi.nlm.nih.gov/pmc/articles/6819238View

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Abstract

This work sought correlates of pitch perception, defined by neural activity above the lower limit of pitch (LLP), in auditory cortical neural ensembles, and examined their topographical distribution. Local field potentials (LFPs) were recorded in eight patients undergoing invasive recordings for pharmaco-resistant epilepsy. Stimuli consisted of bursts of broadband noise followed by regular interval noise (RIN). RIN was presented at rates below and above the LLP to distinguish responses related to the regularity of the stimulus and the presence of pitch itself. LFPs were recorded from human cortical homologues of auditory core, belt, and parabelt regions using multicontact depth electrodes implanted in Heschl’s gyrus (HG) and Planum Temporale (PT), and subdural grid electrodes implanted over lateral superior temporal gyrus (STG). Evoked responses corresponding to the temporal regularity of the stimulus were assessed using autocorrelation of the evoked responses, and occurred for stimuli below and above the LLP. Induced responses throughout the high gamma range (60–200 Hz) were present for pitch values above the LLP, with onset latencies of approximately 70 ms. Mapping of the induced responses onto a common brain space demonstrated variability in the topographical distribution of high gamma responses across subjects. Induced responses were present throughout the length of HG and on PT, which is consistent with previous functional neuroimaging studies. Moreover, in each subject, a region within lateral STG showed robust induced responses at pitch-evoking stimulus rates. This work suggests a distributed representation of pitch processing in neural ensembles in human homologues of core and non-core auditory cortex. •Human neurophysiological recordings seek pitch responses in eight subjects.•Pitch responses defined based on occurrence above lower perceptual limit of pitch.•Induced gamma but not evoked responses follows lower limit criterion.•Responses distributed in core and non-core homologues in auditory cortex.

Evoked

High gamma

Electrocorticography

Neurophysiology

Induced

Details

Title: Subtitle: Direct electrophysiological mapping of human pitch-related processing in auditory cortex
Creators: Phillip E Gander - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Sukhbinder Kumar - Institute of Neuroscience, Newcastle University Medical School, Newcastle, UK
William Sedley - Institute of Neuroscience, Newcastle University Medical School, Newcastle, UK
Kirill V Nourski - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Hiroyuki Oya - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Christopher K Kovach - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Hiroto Kawasaki - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Yukiko Kikuchi - Institute of Neuroscience, Newcastle University Medical School, Newcastle, UK
Roy D Patterson - Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Matthew A Howard - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Timothy D Griffiths - Human Brain Research Laboratory, Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.202, pp.116076-116076
DOI: 10.1016/j.neuroimage.2019.116076
PMID: 31401239
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: NIH, award: DC004290, 1S10OD025025-01, 1S10OD025025-01; DOI: 10.13039/100010269, name: Wellcome Trust, award: WT091681MA
Language: English
Date published: 11/15/2019
Academic Unit: Neurology; Radiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Health, Sport, and Human Physiology
Record Identifier: 9984070686402771

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