Journal article
Direct mitogenic properties of interleukin-1
The Journal of laboratory and clinical medicine, Vol.117(3), pp.234-240
1991
PMID: 2002280
Abstract
Optimal lymphocyte activation generally requires two concurrent signals, one involving the T cell receptor, and another supplied by an accessory cytokine such as interleukin-1. We investigated the conditions under which partial cellular activation occurs in the absence of signal to the T cell receptor. Both murine thymocytes and the T cell clone D10.G4.1 responded to recombinant interleukin-1 in the absence of a mitogenic signal, although the magnitude of these responses was smaller and required higher concentrations of interleukin-1 than if a comitogen had been present. Interleukin-1 and interleukin-6 in combination were synergistic and induced tritiated thymidine incorporation in D10.G4.1 cells equal to 15% of that obtained with optimal concentrations of concanavalin A. Such synergy suggests that a significant degree of nonspecific activation of lymphocytes may occur in the presence of combinations of monocyte-derived cytokines.
Details
- Title: Subtitle
- Direct mitogenic properties of interleukin-1
- Creators
- R. S WALLIS - Case Western Reserve univ., Cleveland OH 44106, United StatesJ FAYEN - Case Western Reserve univ., Cleveland OH 44106, United StatesT. S WIBLIN - Case Western Reserve univ., Cleveland OH 44106, United StatesH FUJIWARA - Case Western Reserve univ., Cleveland OH 44106, United StatesJ. J ELLNER - Case Western Reserve univ., Cleveland OH 44106, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of laboratory and clinical medicine, Vol.117(3), pp.234-240
- PMID
- 2002280
- NLM abbreviation
- J Lab Clin Med
- ISSN
- 0022-2143
- eISSN
- 1532-6543
- Publisher
- Elsevier
- Language
- English
- Date published
- 1991
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094586802771
Metrics
32 Record Views