Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe

Taylor J Abel; Ariane E Rhone; Kirill V Nourski; Hiroto Kawasaki; Hiroyuki Oya; Timothy D Griffiths; Matthew A Howard III; Daniel Tranel

doi:10.1523/jneurosci.3387-14.2015

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Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe

Journal article

Open access

Peer reviewed

Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe

Taylor J Abel, Ariane E Rhone, Kirill V Nourski, Hiroto Kawasaki, Hiroyuki Oya, Timothy D Griffiths, Matthew A Howard III and Daniel Tranel

The Journal of neuroscience, Vol.35(4), pp.1513-1520

01/28/2015

DOI: 10.1523/jneurosci.3387-14.2015

PMCID: PMC4308598

PMID: 25632128

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Abstract

Retrieving the names of friends, loved ones, and famous people is a fundamental human ability. This ability depends on the left anterior temporal lobe (ATL), where lesions can be associated with impaired naming of people regardless of modality (e.g., picture or voice). This finding has led to the idea that the left ATL is a modality-independent convergence region for proper naming. Hypotheses for how proper-name dispositions are organized within the left ATL include both a single modality-independent (heteromodal) convergence region and spatially discrete modality-dependent (unimodal) regions. Here we show direct electrophysiologic evidence that the left ATL is heteromodal for proper-name retrieval. Using intracranial recordings placed directly on the surface of the left ATL in human subjects, we demonstrate nearly identical responses to picture and voice stimuli of famous U.S. politicians during a naming task. Our results demonstrate convergent and robust large-scale neurophysiologic responses to picture and voice naming in the human left ATL. This finding supports the idea of heteromodal (i.e., transmodal) dispositions for proper naming in the left ATL.

Electroencephalography

Semantics

Brain Waves - physiology

Electric Stimulation

Acoustic Stimulation

Humans

Middle Aged

Male

Electrodes, Implanted

Names

Neuropsychological Tests

Mental Recall - physiology

Brain Mapping

Adult

Functional Laterality - physiology

Temporal Lobe - physiology

Photic Stimulation

Spectrum Analysis

Details

Title: Subtitle: Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe
Creators: Taylor J Abel - Department of Neurosurgery and taylor-abel@uiowa.edu
Ariane E Rhone - Department of Neurosurgery and
Kirill V Nourski - Department of Neurosurgery and
Hiroto Kawasaki - Department of Neurosurgery and
Hiroyuki Oya - Department of Neurosurgery and
Timothy D Griffiths - Newcastle Auditory Group, Medical School, Newcastle University, Newcastle-upon-Tyne NE1 7RU, United Kingdom
Matthew A Howard III - Department of Neurosurgery and
Daniel Tranel - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, and
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.35(4), pp.1513-1520
DOI: 10.1523/jneurosci.3387-14.2015
PMID: 25632128
PMCID: PMC4308598
NLM abbreviation: J Neurosci
ISSN: 1529-2401
eISSN: 1529-2401
Publisher: United States
Grant note: F32 NS087664 / NINDS NIH HHS UL1RR024979 / NCRR NIH HHS R01-DC004290 / NIDCD NIH HHS F32-NS087664 / NINDS NIH HHS 091681 / Wellcome Trust R01 DC004290 / NIDCD NIH HHS UL1 RR024979 / NCRR NIH HHS
Language: English
Date published: 01/28/2015
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984002480002771

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