Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells

Craig T Morita; Evan M Beckman; Jack F Bukowski; Yoshimasa Tanaka; Hamid Band; Barry R Bloom; David E Golan; Michael B Brenner

doi:10.1016/1074-7613(95)90178-7

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Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells

Journal article

Open access

Peer reviewed

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells

Craig T Morita, Evan M Beckman, Jack F Bukowski, Yoshimasa Tanaka, Hamid Band, Barry R Bloom, David E Golan and Michael B Brenner

Immunity (Cambridge, Mass.), Vol.3(4), pp.495-507

10/1995

DOI: 10.1016/1074-7613(95)90178-7

PMID: 7584140

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https://doi.org/10.1016/1074-7613(95)90178-7View

Published (Version of record) Open Access

Abstract

Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyrophosphate antigens in the absence of other accessory cells but, under such conditions, required T cell-T cell contact. Recognition required neither the expression of classical MHC class I, MHC class II, or CD1a, CD1b, and CD1c molecules, nor MHC class I or class II peptide loading pathways. Fixed accessory cells also presented the prenyl pyrophosphate antigens to gamma delta T cells. Thus, in contrast with the presentation of conventional peptide antigens, protein antigens, and superantigens to alpha beta T cells, prenyl pyrophosphate antigens are presented to gamma delta T cells through a novel extracellular pathway that does not require antigen uptake, antigen processing, or MHC class I or class II expression. This pathway allows for the rapid recognition of bacteria by gamma delta T cells and suggests that gamma delta T cells play a role in the early response to bacterial infection.

Signal Transduction

Cell Line

Antigen Presentation

Lymphocyte Activation

Humans

Antigens, Bacterial - immunology

Diphosphates - immunology

Lymphocyte Cooperation

Receptors, Antigen, T-Cell, gamma-delta - immunology

T-Lymphocytes - immunology

Details

Title: Subtitle: Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells
Creators: Craig T Morita - Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Evan M Beckman
Jack F Bukowski
Yoshimasa Tanaka
Hamid Band - Brigham and Women's Hospital
Barry R Bloom
David E Golan
Michael B Brenner
Resource Type: Journal article
Publication Details: Immunity (Cambridge, Mass.), Vol.3(4), pp.495-507
DOI: 10.1016/1074-7613(95)90178-7
PMID: 7584140
ISSN: 1074-7613
eISSN: 1097-4180
Grant note: AI28508 / NIAID NIH HHS CA47724 / NCI NIH HHS AR36308 / NIAMS NIH HHS
Language: English
Date published: 10/1995
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094494102771

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