Direct recordings from the auditory cortex in a cochlear implant user

Kirill V Nourski; Christine P Etler; John F Brugge; Hiroyuki Oya; Hiroto Kawasaki; Richard A Reale; Paul J Abbas; Carolyn J Brown; Matthew A Howard III

doi:10.1007/s10162-013-0382-3

Back

Direct recordings from the auditory cortex in a cochlear implant user

Journal article

Open access

Peer reviewed

Direct recordings from the auditory cortex in a cochlear implant user

Kirill V Nourski, Christine P Etler, John F Brugge, Hiroyuki Oya, Hiroto Kawasaki, Richard A Reale, Paul J Abbas, Carolyn J Brown and Matthew A Howard III

Journal of the Association for Research in Otolaryngology, Vol.14(3), pp.435-450

06/2013

DOI: 10.1007/s10162-013-0382-3

PMCID: PMC3642273

PMID: 23519390

Files and links (1)

url

https://doi.org/10.1007/s10162-013-0382-3View

Published (Version of record) Open Access

Abstract

Electrical stimulation of the auditory nerve with a cochlear implant (CI) is the method of choice for treatment of severe-to-profound hearing loss. Understanding how the human auditory cortex responds to CI stimulation is important for advances in stimulation paradigms and rehabilitation strategies. In this study, auditory cortical responses to CI stimulation were recorded intracranially in a neurosurgical patient to examine directly the functional organization of the auditory cortex and compare the findings with those obtained in normal-hearing subjects. The subject was a bilateral CI user with a 20-year history of deafness and refractory epilepsy. As part of the epilepsy treatment, a subdural grid electrode was implanted over the left temporal lobe. Pure tones, click trains, sinusoidal amplitude-modulated noise, and speech were presented via the auxiliary input of the right CI speech processor. Additional experiments were conducted with bilateral CI stimulation. Auditory event-related changes in cortical activity, characterized by the averaged evoked potential and event-related band power, were localized to posterolateral superior temporal gyrus. Responses were stable across recording sessions and were abolished under general anesthesia. Response latency decreased and magnitude increased with increasing stimulus level. More apical intracochlear stimulation yielded the largest responses. Cortical evoked potentials were phase-locked to the temporal modulations of periodic stimuli and speech utterances. Bilateral electrical stimulation resulted in minimal artifact contamination. This study demonstrates the feasibility of intracranial electrophysiological recordings of responses to CI stimulation in a human subject, shows that cortical response properties may be similar to those obtained in normal-hearing individuals, and provides a basis for future comparisons with extracranial recordings.

Cochlear Implants

Hearing Loss, Sensorineural - chemically induced

Electric Stimulation

Hearing Loss, Sensorineural - therapy

Humans

Middle Aged

Female

Auditory Cortex - physiology

Details

Title: Subtitle: Direct recordings from the auditory cortex in a cochlear implant user
Creators: Kirill V Nourski - Department of Neurosurgery, The University of Iowa, Iowa City, IA 52242, USA. kirill-nourski@uiowa.edu
Christine P Etler
John F Brugge
Hiroyuki Oya
Hiroto Kawasaki
Richard A Reale
Paul J Abbas
Carolyn J Brown
Matthew A Howard III
Resource Type: Journal article
Publication Details: Journal of the Association for Research in Otolaryngology, Vol.14(3), pp.435-450
DOI: 10.1007/s10162-013-0382-3
PMID: 23519390
PMCID: PMC3642273
NLM abbreviation: J Assoc Res Otolaryngol
ISSN: 1525-3961
eISSN: 1438-7573
Publisher: United States
Grant note: R01 DC004290 / NIDCD NIH HHS UL1 RR024979 / NCRR NIH HHS UL1RR024979 / NCRR NIH HHS P50 DC000242 / NIDCD NIH HHS R01-DC04290 / NIDCD NIH HHS
Language: English
Date published: 06/2013
Academic Unit: Neurology; Communication Sciences and Disorders; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984002479102771

Metrics

41 Record Views

17 Times Cited - Web of Science