Journal article
Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
Human brain mapping, Vol.20(1), pp.41-49
09/2003
DOI: 10.1002/hbm.10124
PMID: 12953305
Abstract
Magnetic resonance imaging (MRI) of brain functional activity relies principally on changes in cerebral hemodynamics, which are more spatially and temporally distributed than the underlying neuronal activity changes. We present a novel MRI technique for mapping brain functional activity by directly detecting magnetic fields induced by neuronal firing. Using a well-established visuomotor paradigm, the locations and latencies of activations in visual, motor, and premotor cortices were imaged at a temporal resolution of 100 msec and a spatial resolution of 3 mm, and were found to be in consistent with the electrophysiological and functional MRI (fMRI) literature. Signal strength was comparable to traditional event-related fMRI methods: about 1% of the baseline signal. The magnetic-source MRI technique greatly increases the temporal accuracy in detecting neuronal activity, providing a powerful new tool for mapping brain functional organization in human and animals.
Details
- Title: Subtitle
- Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
- Creators
- Jinhu Xiong - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TexasPeter T Fox - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TexasJia-Hong Gao - Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas
- Resource Type
- Journal article
- Publication Details
- Human brain mapping, Vol.20(1), pp.41-49
- DOI
- 10.1002/hbm.10124
- PMID
- 12953305
- NLM abbreviation
- Hum Brain Mapp
- ISSN
- 1065-9471
- eISSN
- 1097-0193
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 9
- Language
- English
- Date published
- 09/2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984083900202771
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