Journal article
Disability and Severe Gastrointestinal Hemorrhage. A Prospective Study of Community-Dwelling Older Persons
Journal of the American Geriatrics Society (JAGS), Vol.42(8), pp.816-825
08/1994
DOI: 10.1111/j.1532-5415.1994.tb06552.x
PMID: 8046191
Abstract
Objective: To describe the occurrence of severe gastrointestinal bleeding in community-dwelling older persons and to examine whether disability is a risk factor for this life-threatening condition independent of other known predictors.
Design: Prospective cohort survey.
Setting: Three communities of the Established Populations for Epidemiologic Studies of the Elderly (EPESE).
Participants: 8205 persons age > or = 68 years.
Measurements: The hospital discharge diagnoses provided by the Medicare Provider Analysis and Review files and the death certificates were prospectively surveyed for 3 years. Those with at least 1 discharge diagnosis of gastrointestinal bleeding and who received a blood transfusion or died were identified as cases of severe gastrointestinal hemorrhage. Physical disability, cognitive function, smoking and alcohol intake habits, body mass index, blood pressure, chronic conditions, number of hospital admissions in past year and medications taken were assessed at baseline.
Results: The occurrence rate of severe gastrointestinal bleeding was 10.8 per 1000 person-years (241 events/22,277 person-years). In proportional hazards regression models, compared with no disability, > or = 1 disabilities in the Rosow-Breslau scale (RR = 2.1, 95% CI = 1.5-2.9), and > or = 1 ADLs limitations (RR = 3.1, 95% CI = 2.1-4.6) independently predicted gastrointestinal hemorrhage after adjusting for age, gender, body mass index, comorbidity, number of hospital admissions, blood pressure, intake of coumarin, corticosteroids, aspirin and other nonsteroidal anti-inflammatory drugs.
Conclusions: In this prospective analysis, disability is an independent predictor of gastrointestinal hemorrhage. Further studies are needed to explain the mechanisms by which disability may cause gastrointestinal hemorrhage. Because physical disability is potentially modifiable, strategies to lower the risk of gastrointestinal bleeding should be evaluated.
Details
- Title: Subtitle
- Disability and Severe Gastrointestinal Hemorrhage. A Prospective Study of Community-Dwelling Older Persons
- Creators
- Marco Pahor - Department of Gerontology, Catholic University, Rome, ItalyJack M Guralnik - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MarylandMarcel E Salive - Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MarylandElizabeth A Chrischilles - Department of Preventive Medicine and Environmental Health, The University of Iowa, Iowa City, IowaAndrea Manto - Department of Gerontology, Catholic University, Rome, ItalyRobert B Wallace - Department of Preventive Medicine and Environmental Health, The University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.42(8), pp.816-825
- DOI
- 10.1111/j.1532-5415.1994.tb06552.x
- PMID
- 8046191
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 10
- Language
- English
- Date published
- 08/1994
- Academic Unit
- Pharmacy; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984214847302771
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