Journal article
Discordant findings on preoperative imaging for primary hyperparathyroidism and thyroid disease: Choosing the path to follow
Surgery, Vol.166(4), pp.678-685
10/01/2019
DOI: 10.1016/j.surg.2019.05.057
PMID: 31466855
Abstract
Background: Preoperative localization of abnormal parathyroid glands in primary hyperparathyroidism is often obtained by sestamibi, and ultrasonography. We aimed to identify which modality is most accurate when laterality of abnormal glands on preoperative imaging is discordant.
Methods: A single institution retrospective review identified 112 consecutive patients with primary hyperparathyroidism who underwent successful parathyroidectomy and sestamibi with pertechnetate.
Results: Sestamibi with pertechnetate had a sensitivity of 72% and positive predictive value of 90%; ultrasonography had sensitivity of 50% and positive predictive value 80%. Patients with thyroiditis had lesser sensitivity and positive predictive value on sestamibi with pertechnetate (53% and 77%, respectively), in contrast to ultrasonography (54%, 88%, respectively). The sensitivity and positive predictive value of sestamibi with pertechnetate and ultrasonography did not differ in patients with thyroid nodules. Seventeen patients (15%) had discordant laterality on preoperative imaging. In discordant cases, sestamibi with pertechnetate was correct in 53% overall but in only 17% of those with thyroiditis (P = .01), whereas ultrasonography was correct in 26% overall but in 50% of those with thyroiditis (P = .01).
Conclusion: Thyroiditis decreased the sensitivity and positive predictive value of sestamibi with pertechnetate in primary hyperparathyroidism. In patients with discordant laterality on preoperative imaging, sestamibi with pertechnetate is the more accurate choice to guide operative planning, although ultrasonography may be a better guide in those with thyroiditis. (C) 2019 Published by Elsevier Inc.
Details
- Title: Subtitle
- Discordant findings on preoperative imaging for primary hyperparathyroidism and thyroid disease: Choosing the path to follow
- Creators
- Anna C. Beck - University of IowaAbhishek K. Kashyap - University of Iowa Hospitals and ClinicsGeeta Lal - University of IowaJames R. Howe - University of Iowa Hospitals and ClinicsRonald J. Weigel - University of Iowa Hospitals and ClinicsMichael M. Graham - University of Iowa Hospitals and ClinicsSonia L. Sugg - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Surgery, Vol.166(4), pp.678-685
- DOI
- 10.1016/j.surg.2019.05.057
- PMID
- 31466855
- NLM abbreviation
- Surgery
- ISSN
- 0039-6060
- eISSN
- 1532-7361
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- T32CA148062 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32CA148062 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Surgery; Radiation Oncology; Biochemistry and Molecular Biology
- Record Identifier
- 9984284328302771
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