Journal article
Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis
The American journal of the medical sciences, Vol.327(4), pp.188-195
04/2004
DOI: 10.1097/00000441-200404000-00004
PMID: 15084914
Abstract
Two autoimmune murine models—proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)—were developed in parent strains, F1 and F2 hybrids of major histocompatibility complex (MHC)–matched (H-2d) BALB/c × DBA/2 and MHC-unmatched (H-2d/H-2q) BALB/c × DBA/1 intercrosses. The major goal of this comparative study was to identify disease (model)-specific (PGIA or CIA) and shared clinical and immunologic loci in 2 types of genetic intercrosses. Qualitative (binary/susceptibility) and quantitative (severity and onset) clinical trait loci were separated and analyzed independently or together with various pathophysiologic/immunologic traits, such as antigen-specific T- and B-cell responses and cytokine production. The major quantitative trait locus (QTL) was the MHC on chromosome 17, which was especially dominant in CIA. In addition, chromosomes 3, 5, 10, and × contained shared clinical loci in both models, and a total of 8 QTLs (clinical traits together with immunologic traits) were colocalized in PGIA and CIA.
Details
- Title: Subtitle
- Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis
- Creators
- V.A AdarichevA.B NesterovitchJ.J JacobsT.T Glant - Section of Biochemistry and Molecular Biology, Departments of Orthopedic Surgery, and Biochemistry, Chicago, IllinoisS Szanto - Section of Biochemistry and Molecular Biology, Departments of Orthopedic Surgery and Biochemistry, Chicago, IllinoisG Firneisz - Section of Biochemistry and Molecular Biology, Departments of Orthopedic Surgery and Biochemistry, Chicago, IllinoisJ ZhangK MikeczA Finnegan - Department of Internal Medicine (Section of Rheumatology), Chicago, IllinoisJ.P Oswald - Comparative Research Center, Rush University at Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.327(4), pp.188-195
- Publisher
- Elsevier Inc
- DOI
- 10.1097/00000441-200404000-00004
- PMID
- 15084914
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 04/2004
- Academic Unit
- Pathology
- Record Identifier
- 9984047673102771
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