Disease Burden and Variability in Sarcoidosis

Alicia K Gerke; Marc A Judson; Yvette C Cozier; Daniel A Culver; Laura L Koth

doi:10.1513/AnnalsATS.201707-564OT

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Disease Burden and Variability in Sarcoidosis

Journal article

Open access

Peer reviewed

Disease Burden and Variability in Sarcoidosis

Alicia K Gerke, Marc A Judson, Yvette C Cozier, Daniel A Culver and Laura L Koth

Annals of the American Thoracic Society, Vol.14(Supplement_6), pp.S421-S428

12/2017

DOI: 10.1513/AnnalsATS.201707-564OT

PMCID: PMC5802572

PMID: 29087725

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Abstract

Sarcoidosis is a systemic inflammatory disease with substantial morbidity and increasing mortality. As part of the National Heart, Lung, and Blood Institute's workshop to better understand this disease and improve the outcomes of patients with sarcoidosis, we reviewed the available data on health care burden and outcomes of this disease in the United States. Disparities in outcomes exist by race, ethnicity, sex, and socioeconomic groups, with African Americans having disproportionately more severe disease. Mortality rates are highest in African Americans, but may be increasing in white individuals. The health care burden of sarcoidosis is defined not only by its somatic manifestations, but is also greatly impacted by psychosocial, economic, and comorbid conditions associated with this disease. Fatigue, depression, cognitive dysfunction, treatment side effects, and pain syndromes are highly prevalent in this population and contribute to poor outcomes. The direct and indirect economic costs to patients and society are likely also substantial, although not well defined. We recommend leveraging existing and future technology and infrastructure to more accurately define and monitor the overall total sarcoidosis-attributable health care burden and patient outcomes in the United States.

Sarcoidosis - epidemiology

National Heart, Lung, and Blood Institute (U.S.)

Sarcoidosis - mortality

United States

Humans

Sarcoidosis - ethnology

African Americans

Cost of Illness

European Continental Ancestry Group

Details

Title: Subtitle: Disease Burden and Variability in Sarcoidosis
Creators: Alicia K Gerke - 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Iowa, Iowa City, Iowa
Marc A Judson - 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Albany Medical College, Albany, New York
Yvette C Cozier - 3 Slone Epidemiology Center at Boston University, Boston, Massachusetts
Daniel A Culver - 4 Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio; and
Laura L Koth - 5 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California
Resource Type: Journal article
Publication Details: Annals of the American Thoracic Society, Vol.14(Supplement_6), pp.S421-S428
DOI: 10.1513/AnnalsATS.201707-564OT
PMID: 29087725
PMCID: PMC5802572
NLM abbreviation: Ann Am Thorac Soc
ISSN: 2325-6621
eISSN: 2325-6621
Publisher: American Thoracic Society
Grant note: P30 ES005605 / NIEHS NIH HHS R01 CA058420 / NCI NIH HHS UM1 CA164974 / NCI NIH HHS K01 HL088709 / NHLBI NIH HHS K23 HL114640 / NHLBI NIH HHS U01 HL112696 / NHLBI NIH HHS
Language: English
Date published: 12/2017
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094350002771

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