Journal article
Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States
British journal of haematology, Vol.170(1), pp.85-95
07/2015
DOI: 10.1111/bjh.13399
PMCID: PMC5076864
PMID: 25851937
Abstract
Data from the National LymphoCare Study (a prospective, multicentre registry that enrolled follicular lymphoma (FL) patients from 2004 to 2007) were used to determine disease characteristics, treatment patterns, outcomes and prognosis for elderly FL (eFL) patients. Of 2650 FL patients, 209 (8%) were aged >80 years; these eFL patients more commonly had grade 3 disease, less frequently received chemoimmunotherapy and anthracyclines, and had lower response rates when compared to younger patients. With a median follow-up of 6.9 years, 5-year overall survival (OS) for eFL patients was 59%; 38% of deaths were lymphoma-related. No treatment produced superior OS among eFL patients. In multivariate Cox models, anaemia, B-symptoms and male sex predicted worse OS (P < 0.01); a prognostic index of these factors (0, 1 or ≥ 2 present) predicted OS [hazard ratio (95% CI): ≥ 2 vs. 0, 4.72 (2.38-9.33); 1 vs. 0, 2.63 (1.39-4.98)], with a higher concordance index (0.63) versus the Follicular Lymphoma International Prognostic Index (0.55). The index was validated in an independent cohort. In the largest prospective US-based eFL cohort, no optimal therapy was identified and nearly 40% of deaths were lymphoma-related, representing baseline outcomes in the modern era.
Details
- Title: Subtitle
- Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States
- Creators
- Chadi Nabhan - Department of Medicine Section of Hematology and Oncology, The University of Chicago Comprehensive Cancer Center, Chicago, IL, USAMichelle Byrtek - Genentech Inc, South San Francisco, CA, USAAshish Rai - Emory University, Atlanta, GA, USAKeith Dawson - Genentech Inc, South San Francisco, CA, USAXiaolei Zhou - RTI Health Solutions, Research Triangle Park, NC, USABrian K Link - University of Iowa, Iowa, IA, USAJonathan W Friedberg - University of Rochester, Rochester, NY, USAAndrew D Zelenetz - Memorial Sloan Kettering Cancer Center, New York, NY, USAMatthew J Maurer - Mayo Clinic, Rochester, MN, USAJames R Cerhan - Mayo Clinic, Rochester, MN, USAChristopher R Flowers - Emory University, Atlanta, GA, USA
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.170(1), pp.85-95
- DOI
- 10.1111/bjh.13399
- PMID
- 25851937
- PMCID
- PMC5076864
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Grant note
- P30 CA008748 / NCI NIH HHS
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984094383302771
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