Journal article
Disease-modifying therapeutic directions for Lewy-Body dementias
Frontiers in neuroscience, Vol.9, pp.293-293
2015
DOI: 10.3389/fnins.2015.00293
PMCID: PMC4542461
PMID: 26347604
Abstract
Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB.
Details
- Title: Subtitle
- Disease-modifying therapeutic directions for Lewy-Body dementias
- Creators
- Qiang Zhang - Department of Neurology, University of IowaYoung-Cho Kim - Department of Neurology, University of IowaNandakumar S Narayanan - Department of Neurology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in neuroscience, Vol.9, pp.293-293
- DOI
- 10.3389/fnins.2015.00293
- PMID
- 26347604
- PMCID
- PMC4542461
- NLM abbreviation
- Front Neurosci
- ISSN
- 1662-4548
- eISSN
- 1662-453X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2015
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020763202771
Metrics
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