Journal article
Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States
American journal of hematology, Vol.91(8), pp.770-775
08/01/2016
DOI: 10.1002/ajh.24401
PMCID: PMC5564298
PMID: 27124800
Abstract
We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004-2014). Among evaluable males (n=1277) and females (n=1375) with FL, females less commonly received anthracyclines and were more likely to receive rituximab monotherapy. Overall response rates were comparable between sex groups. With a median follow-up of 8.1 years, male sex emerged as an adverse factor for PFS (HR, 0.84, 95% CI, 0.72-0.97). Lymphoma-related mortality (HR, 0.46; 0.23-0.93) and overall survival (HR, 0.63; 0.41-0.97) favored females aged 60 years. There are subtle differences in outcomes between male and female FL patients diagnosed and treated in the contemporary era. These data represent the largest prospective analysis of FL patients in the USA based on sex and can aid design of clinical trials for this disease. Am. J. Hematol. 91:770-775, 2016. (c) 2016 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States
- Creators
- Chadi Nabhan - University of ChicagoXiaolei Zhou - RTI Health SolutionsBann-Mo DayKeith DawsonAndrew D. Zelenetz - Memorial Sloan Kettering Cancer CenterJonathan W. Friedberg - University of RochesterJames R. Cerhan - Mayo Clinic in FloridaBrian K. Link - University of IowaChristopher R. Flowers - Emory University
- Resource Type
- Journal article
- Publication Details
- American journal of hematology, Vol.91(8), pp.770-775
- Publisher
- Wiley
- DOI
- 10.1002/ajh.24401
- PMID
- 27124800
- PMCID
- PMC5564298
- ISSN
- 0361-8609
- eISSN
- 1096-8652
- Number of pages
- 6
- Grant note
- Genentech Inc./F. Hoffmann-La Roche Ltd. Genentech Inc., South San Francisco, CA/F. Hoffmann-La Roche Ltd, Basel, Switzerland P30CA008748; P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359783502771
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