Disinfection of immature teeth with a triple antibiotic paste

William Windley III; Fabricio Teixeira; Linda Levin; Asgeir Sigurdsson; Martin Trope

doi:10.1097/01.don.0000148143.80283.ea

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Disinfection of immature teeth with a triple antibiotic paste

Journal article

Peer reviewed

Disinfection of immature teeth with a triple antibiotic paste

William Windley III, Fabricio Teixeira, Linda Levin, Asgeir Sigurdsson and Martin Trope

Journal of endodontics, Vol.31(6), pp.439-443

06/2005

DOI: 10.1097/01.don.0000148143.80283.ea

PMID: 15917683

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Abstract

This study assessed the efficacy of a triple antibiotic paste in the disinfection of immature dog teeth with apical periodontitis. The canals were sampled before (S1) and after (S2) irrigation with 1.25% NaOCL and after dressing with a triple antibiotic paste (S3), consisting of metronidazole, ciprofloxacin, and minocycline. At S1, 100% of the samples cultured positive for bacteria with a mean CFU count of 1.7 x 10. At S2, 10% of the samples cultured bacteria-free with a mean CFU count of 1.4 x 10. At S3, 70% of the samples cultured bacteria-free with a mean CFU count of only 26. Reductions in mean CFU counts between S1 and S2 (p < 0.0001) as well as between S2 and S3 (p < 0.0001) were statistically significant. These results indicate the effectiveness of a triple antibiotic paste in the disinfection of immature teeth with apical periodontitis.

Animals

Bacteria, Anaerobic - drug effects

Ciprofloxacin - pharmacology

Ciprofloxacin - therapeutic use

Colony Count, Microbial

Dental Pulp - blood supply

Dogs

Drug Therapy, Combination - pharmacology

Drug Therapy, Combination - therapeutic use

Metronidazole - pharmacology

Metronidazole - therapeutic use

Minocycline - pharmacology

Minocycline - therapeutic use

Neovascularization, Physiologic

Periapical Periodontitis - drug therapy

Root Canal Irrigants - pharmacology

Root Canal Irrigants - therapeutic use

Sodium Hypochlorite - pharmacology

Sodium Hypochlorite - therapeutic use

Tooth Apex - growth & development

Details

Title: Subtitle: Disinfection of immature teeth with a triple antibiotic paste
Creators: William Windley III - University of North Carolina at Chapel Hill
Fabricio Teixeira - University of North Carolina at Chapel Hill
Linda Levin - University of North Carolina at Chapel Hill
Asgeir Sigurdsson - University of North Carolina at Chapel Hill
Martin Trope - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Journal of endodontics, Vol.31(6), pp.439-443
DOI: 10.1097/01.don.0000148143.80283.ea
PMID: 15917683
ISSN: 0099-2399
eISSN: 1878-3554
Language: English
Date published: 06/2005
Academic Unit: Endodontics
Record Identifier: 9984367751502771

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187 Times Cited - Web of Science