Journal article
Disparities in Diagnosis, Treatment Access, and Time to Treatment Among Hispanic Men With Metastatic Prostate Cancer
JCO oncology practice, Vol.19(8), pp.645-653
08/01/2023
DOI: 10.1200/OP.23.00040
PMCID: PMC10424902
PMID: 37262399
Abstract
PURPOSEReporting racial/ethnic disparities in aggregate obscures within-group heterogeneity. We sought to identify disparities in diagnosis and treatment in Hispanic subpopulations with metastatic prostate cancer (mPCa).METHODSWe disaggregated men with prostate adenocarcinoma from the National Cancer Database from 2004 to 2017 by racial subgroup and Hispanic background. We assessed (1) presenting with mPCa, (2) receiving any treatment, and (3) receiving delayed treatment beyond 90 days. Logistic regression and adjusted odds ratios (aOR) were reported.RESULTSHispanic men had greater odds of presenting with mPCa (aOR, 1.54; 95% CI, 1.50 to 1.58; P < .001) compared with non-Hispanic White (NHW) men. All Hispanic racial subgroups were more likely to present with mPCa, with the highest risk in Hispanic Black (HB) men (aOR, 1.68; 95% CI, 1.46 to 1.93; P < .01). Men from all Hispanic backgrounds had higher odds of presenting with mPCa, especially Mexican men (aOR, 1.99; 95% CI, 1.86 to 2.12; P < .01). Hispanic men were less likely to receive any treatment (aOR, 0.60; 95% CI, 0.53 to 0.67; P < .001), and this effect was particularly strong for Hispanic White patients (aOR, 0.58; 95% CI, 0.52 to 0.66; P < .001) and Dominican men (aOR, 0.52; 95% CI, 0.28 to 0.98; P = .044). Hispanic men were more likely to experience treatment delays compared with NHW men (aOR, 1.38; 95% CI, 1.26 to 1.52; P < .001) and in particular HB (aOR, 1.83; 95% CI, 1.22 to 2.75; P = .002) and South/Central American men (aOR, 1.48; 95% CI, 1.07 to 2.04; P = .018).CONCLUSIONDifferences exist in stage at presentation, treatment receipt, and delays in treatment on disaggregation by racial subgroup and Hispanic heritage. We need to study the potential mechanisms of the observed variations to help develop targeted interventions.
Details
- Title: Subtitle
- Disparities in Diagnosis, Treatment Access, and Time to Treatment Among Hispanic Men With Metastatic Prostate Cancer
- Creators
- Helen Y. Hougen - University of MiamiNishwant Swami - University of Massachusetts Chan Medical SchoolEdward Christopher Dee - Memorial Sloan Kettering Cancer CenterMohammed Alshalalfa - Sylvester Comprehensive Cancer CenterKarthik Meiyappan - University of MiamiNarjust Florez - Harvard Med Sch, Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA USAFrank J. Penedo - University of MiamiPaul L. Nguyen - Dana-Farber Cancer InstituteSanoj Punnen - Sylvester Comprehensive Cancer CenterBrandon A. Mahal - Sylvester Comprehensive Cancer Center
- Resource Type
- Journal article
- Publication Details
- JCO oncology practice, Vol.19(8), pp.645-653
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1200/OP.23.00040
- PMID
- 37262399
- PMCID
- PMC10424902
- ISSN
- 2688-1527
- eISSN
- 2688-1535
- Number of pages
- 11
- Grant note
- Department of Defense; United States Department of Defense Sylvester Comprehensive Cancer Center P30 CA008748 / Cancer Center Support Grant from the National Cancer Institute Prostate Cancer Foundation American Society for Radiation Oncology
- Language
- English
- Date published
- 08/01/2023
- Academic Unit
- Urology
- Record Identifier
- 9984701549302771
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