Journal article
Disparities in breast cancer subtypes among women in the lower Mississippi Delta Region states
Cancer causes & control, Vol.30(6), pp.591-601
06/01/2019
DOI: 10.1007/s10552-019-01168-0
PMID: 30972520
Abstract
To describe and elucidate rates in breast cancer incidence by subtype in the federally designated Mississippi Delta Region, an impoverished region across eight Southern/Midwest states with a high proportion of Black residents and notable breast cancer mortality disparities.Cancer registry data from seven LMDR states (Missouri was not included because of permission issues) were used to explore breast cancer incidence differences by subtype between the LMDR’s Delta and non-Delta Regions and between White and Black women within the Delta Region (2012–2014). Overall and subtype-specific age-adjusted incidence rates and rate ratios were calculated. Multilevel negative binomial regression models were used to evaluate how individual-level and area-level factors, like race/ethnicity and poverty level, respectively, affect rates of breast cancers by subtype.Women in the Delta Region had higher rates of triple-negative breast cancer, the most aggressive subtype, than women in the non-Delta (17.0 vs. 14.4 per 100,000), but the elevated rate was attenuated to non-statistical significance in multivariable analysis. Urban Delta women also had higher rates of triple-negative breast cancer than non-Delta urban women, which remained in multivariable analysis. In the Delta Region, Black women had higher overall breast cancer rates than their White counterparts, which remained in multivariable analysis.Higher rates of triple-negative breast cancer in the Delta Region may help explain the Region’s mortality disparity. Further, an important area of future research is to determine what unaccounted for individual-level or social area-level factors contribute to the elevated breast cancer incidence rate among Black women in the Delta Region.
Details
- Title: Subtitle
- Disparities in breast cancer subtypes among women in the lower Mississippi Delta Region states
- Creators
- Whitney Zahnd - 0000 0000 9075 106X grid.254567.7 Department of Health Services Policy & Management, Arnold School of Public Health University of South Carolina 915 Greene Street Columbia SC 29208 USARecinda Sherman - grid.422731.1 North American Association of Central Cancer Registries 2050 W. Iles Suite A Springfield IL 62704 USAHillary Klonoff-Cohen - 0000 0004 1936 9991 grid.35403.31 Department of Kinesiology and Community Health University of Illinois Urbana-Champaign 1206 S. Fourth St. Champaign IL 61820 USASara McLafferty - 0000 0004 1936 9991 grid.35403.31 Department of Geography and Geographic Information Science University of Illinois Urbana-Champaign 1301 W. Green St. Urbana IL 61801 USASusan Farner - 0000 0004 1936 9991 grid.35403.31 Department of Kinesiology and Community Health University of Illinois Urbana-Champaign 1206 S. Fourth St. Champaign IL 61820 USAKarin Rosenblatt - 0000 0004 1936 9991 grid.35403.31 Department of Kinesiology and Community Health University of Illinois Urbana-Champaign 1206 S. Fourth St. Champaign IL 61820 USA
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.30(6), pp.591-601
- Publisher
- Springer International Publishing
- DOI
- 10.1007/s10552-019-01168-0
- PMID
- 30972520
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Language
- English
- Date published
- 06/01/2019
- Academic Unit
- Health Management and Policy
- Record Identifier
- 9984214673602771
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