Journal article
Disposition of PCB 11 in Mice Following Acute Oral Exposure
Chemical research in toxicology, Vol.34(4), pp.988-991
04/19/2021
DOI: 10.1021/acs.chemrestox.1c00067
PMCID: PMC8058299
PMID: 33734669
Abstract
PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung similar to muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.
Details
- Title: Subtitle
- Disposition of PCB 11 in Mice Following Acute Oral Exposure
- Creators
- Chun-Yun Zhang - University of IowaCarolyn R. Klocke - University of California, DavisPamela J. Lein - University of California, DavisHans-Joachim Lehmler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.34(4), pp.988-991
- DOI
- 10.1021/acs.chemrestox.1c00067
- PMID
- 33734669
- PMCID
- PMC8058299
- NLM abbreviation
- Chem Res Toxicol
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Publisher
- Amer Chemical Soc
- Number of pages
- 4
- Grant note
- ES005605; ES013661; ES014901; ES031098 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 04/19/2021
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984285537702771
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