Journal article
Disrupting dorsal hippocampus impairs category learning in rats
Neurobiology of learning and memory, Vol.212, 107941
07/2024
DOI: 10.1016/j.nlm.2024.107941
PMID: 38768684
Abstract
Categorization requires a balance of mechanisms that can generalize across common features and discriminate against specific details. A growing literature suggests that the hippocampus may accomplish these mechanisms by using fundamental mechanisms like pattern separation, pattern completion, and memory integration. Here, we assessed the role of the rodent dorsal hippocampus (HPC) in category learning by combining inhibitory DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) and simulations using a neural network model. Using touchscreens, we trained rats to categorize distributions of visual stimuli containing black and white gratings that varied along two continuous dimensions. Inactivating the dorsal HPC impaired category learning and generalization, suggesting that the rodent HPC plays an important role during categorization. Hippocampal inactivation had no effect on a control discrimination task that used identical trial procedures as the categorization tasks, suggesting that the impairments were specific to categorization. Model simulations were conducted with variants of a neural network to assess the impact of selective deficits on category learning. The hippocampal inactivation groups were best explained by a model that injected random noise into the computation that compared the similarity between category stimuli and existing memory representations. This model is akin to a deficit in mechanisms of pattern completion, which retrieves similar memory representations using partial information.
Details
- Title: Subtitle
- Disrupting dorsal hippocampus impairs category learning in rats
- Creators
- Matthew B. Broschard - University of IowaJangjin Kim - Kyungpook National UniversityBradley C. Love - University College LondonHunter E. Halverson - University of IowaJohn H. Freeman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.212, 107941
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nlm.2024.107941
- PMID
- 38768684
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Grant note
- National Institutes of Health: P01-HD080679 Wellcome Trust Investigator Award: WT106931MA
National Institutes of Health Grant P01-HD080679 to J.H.F. and B.C. L. and Wellcome Trust Investigator Award WT106931MA to B.C.L.
- Language
- English
- Electronic publication date
- 05/19/2024
- Date published
- 07/2024
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984628048302771
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