Journal article
Disruption of Phosphatidylcholine Monolayers and Bilayers by Perfluorobutane Sulfonate
The journal of physical chemistry. B, Vol.116(33), pp.9999-10007
08/23/2012
DOI: 10.1021/jp304412p
PMCID: PMC3464004
PMID: 22834732
Abstract
Perfluoroalkyl acids (PFAAs) are persistent environmental contaminants resistant to biological and chemical degradation due to the presence of carbon-fluorine bonds. These compounds exhibit developmental toxicity
in
vitro and
in
vivo. The mechanisms of toxicity may involve partitioning into lipid bilayers. We investigated the interaction between perfluorobutane sulfonate (PFBS), an emerging PFAA, and model phosphatidylcholine (PC) lipid assemblies (i.e., dimyristoyl-, dipalmitoyl- and distearylphosphatidylcholine) using fluorescence anisotropy and Langmuir monolayer techniques. PFBS decreased the transition temperature and transition width of PC bilayers. The apparent membrane partition coefficients ranged from 4.9 × 10
2
to 8.2 × 10
2
. The effects on each PC were comparable. The limiting molecular area of PC monolayers increased and the surface pressure at collapse decreased in a concentration-dependent manner. The compressibility of all three PCs was decreased by PFBS. In summary, PFBS disrupted different model lipid assemblies indicating potential for PFBS to be a human toxicant. However the effects of PFBS are not as pronounced as those seen with longer chain PFAAs.
Details
- Title: Subtitle
- Disruption of Phosphatidylcholine Monolayers and Bilayers by Perfluorobutane Sulfonate
- Creators
- E. Davis Oldham - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242Wei Xie - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242Amir M Farnoud - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242Jennifer Fiegel - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242Hans-Joachim Lehmler - Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- The journal of physical chemistry. B, Vol.116(33), pp.9999-10007
- DOI
- 10.1021/jp304412p
- PMID
- 22834732
- PMCID
- PMC3464004
- NLM abbreviation
- J Phys Chem B
- ISSN
- 1520-6106
- eISSN
- 1520-5207
- Language
- English
- Date published
- 08/23/2012
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering; Iowa Superfund Research Program
- Record Identifier
- 9984001095902771
Metrics
23 Record Views