Journal article
Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome
Blood, Vol.124(23), pp.3409-3419
11/27/2014
DOI: 10.1182/blood-2014-07-587642
PMCID: PMC4246038
PMID: 25253772
Abstract
Key Points hSWI/SNF requires WASp to remodel IFNG and TBX21 loci in T-helper (TH)1 cells. WAS-causing but not XLT-causing hot-spot mutations impair SWI/SNF-activity at TH1 gene promoters.
Details
- Title: Subtitle
- Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome
- Creators
- Koustav Sarkar - Division of Pediatric Hematology-Oncology, University of Iowa Children’s Hospital, Iowa City, IA; and, Division of Pediatric Hematology-Oncology, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PASanjoy Sadhukhan - Division of Pediatric Hematology-Oncology, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PASeong-Su Han - Division of Pediatric Hematology-Oncology, University of Iowa Children’s Hospital, Iowa City, IA; andYatin M Vyas - Division of Pediatric Hematology-Oncology, University of Iowa Children’s Hospital, Iowa City, IA; and, Division of Pediatric Hematology-Oncology, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.124(23), pp.3409-3419
- DOI
- 10.1182/blood-2014-07-587642
- PMID
- 25253772
- PMCID
- PMC4246038
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Language
- English
- Date published
- 11/27/2014
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093357102771
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