Journal article
Dissecting human cortical similarity networks across the lifespan
Neuron (Cambridge, Mass.), Vol.113(19), pp.3275-3295.e11
10/2025
DOI: 10.1016/j.neuron.2025.06.018
PMID: 40706587
Abstract
The human cortex exhibits remarkable morphometric similarity between regions; however, the form and extent of lifespan network remodeling remain unknown. Here, we show the spatiotemporal maturation of morphometric brain networks, using multimodal neuroimaging data from 33,937 healthy participants aged 0–80 years. Global architecture matures from birth to early adulthood through enhanced modularity and small worldness. Early development features cytoarchitecturally distinct remodeling: sensory cortices exhibit increased morphometric differentiation, paralimbic cortices show increased morphometric similarity, and association cortices retain stable hub roles. Morphology-function coupling peaks in early adolescence and then decreases, supporting protracted functional maturation. These growth patterns of morphometric networks are correlated with gene expression related to synaptic signaling, neurodevelopment, and metabolism. Normative models based on morphometric networks identify person-specific, connectivity-phenotypic deviations in 1,202 patients with brain disorders. These data provide a blueprint for elucidating the principle of cortical network reconfiguration and a benchmark for quantifying interindividual network variations.
•We analyze lifespan maturation patterns in morphometric networks in the human brain•Sensory and association cortices show divergent maturation in morphometric networks•Morphometric network growth correlates with function, metabolism, and transcriptome•Morphometric network-based normative models detect individual brain deviations
Liang et al. characterize the lifespan maturation of human cortical morphometric networks (0–80 years, 33,937 participants), revealing distinct trajectories between sensory and association cortices. These developmental patterns correlate with functional, metabolic, and transcriptomic profiles. Morphometric network-based normative modeling identifies disorder-specific, connectivity-phenotypic deviations, establishing a quantitative benchmark for assessing individual brain variations.
Details
- Title: Subtitle
- Dissecting human cortical similarity networks across the lifespan
- Creators
- Xinyuan Liang - Beijing Normal UniversitySterling JohnsonLianglong Sun - Beijing Normal UniversitySanjay AsthanaMingrui Xia - Beijing Normal UniversityCynthia M. CarlssonTengda Zhao - Beijing Normal UniversitySteven G. PotkinGaolang Gong - Beijing Normal UniversityAdrian PredaQiongling Li - Beijing Normal UniversityQian Wang - Beijing Normal UniversityMichelle RainkaDana NguyenQian Yu - Beijing Normal UniversityDouglas W. ScharreXuhong Liao - Beijing Normal UniversityYanchao Bi - Chinese Institute for Brain ResearchMaria KatakiPierre TariotPindong Chen - Institute of AutomationAnahita AdeliZaixu Cui - Chinese Institute for Brain ResearchRui Chen - Beijing Normal UniversityEarl A. ZimmermanStephanie ReederYuan Chen - First Affiliated Hospital of Zhengzhou UniversityDzintra CelminsDingna Duan - Beijing Normal UniversityTaolin Chen - West China Hospital of Sichuan UniversityAlice D. BrownVernice BatesJingliang Cheng - First Affiliated Hospital of Zhengzhou UniversityGodfrey D. PearlsonChenxuan Pang - Beijing Normal UniversityYuqi Cheng - First Affiliated Hospital of Kunming Medical UniversityKaren BlankHoracio CapoteZhengjia Dai - Beijing Normal UniversityKaren AndersonYao Deng - Beijing Normal UniversityYuyin Ding - Beijing Normal UniversityQi Dong - Beijing Normal UniversityJia-Hong Gao - Peking UniversityQiyong Gong - Sichuan UniversityYing Han - Capital Medical UniversityZaizhu Han - Beijing Normal UniversityChu-Chung Huang - East China Normal UniversityRuiwang Huang - Beijing Normal UniversityRan Huo - Peking University Third HospitalLingjiang Li - Hunan Institute of Mental HealthQixiang Lin - Beijing Normal UniversityBangshan Liu - Hunan Institute of Mental HealthChao Liu - Beijing Normal UniversityNingyu Liu - Beijing Normal UniversityYing Liu - Peking UniversityYong Liu - Beijing Academy of Artificial IntelligenceJing Lu - Beijing Normal UniversityLeilei Ma - Beijing Normal UniversityWeiwei Men - Peking UniversityShaozheng Qin - Beijing Normal UniversityWen Qin - Tianjin Medical University General HospitalJiang Qiu - Southwest UniversityShijun Qiu - First Affiliated Hospital of Guangzhou University of Chinese MedicineTianmei Si - Peking UniversityShuping Tan - Beijing HuiLongGuan HospitalYanqing Tang - China Medical UniversitySha Tao - Beijing Normal UniversityDawei Wang - Qilu Hospital of Shandong UniversityFei Wang - China Medical UniversityJiali Wang - Beijing Normal UniversityJinhui Wang - South China Normal UniversityPan Wang - Tianjin Huanhu HospitalXiaoqin Wang - Southwest UniversityYanpei Wang - Beijing Normal UniversityDongtao Wei - Southwest UniversityYankun Wu - Peking UniversityPeng Xie - The Affiliated Yongchuan Hospital of Chongqing Medical UniversityXiufeng Xu - First Affiliated Hospital of Kunming Medical UniversityYuehua Xu - Beijing Normal UniversityZhilei Xu - Beijing Normal UniversityLiyuan Yang - Beijing Normal UniversityChunshui Yu - Tianjin Medical University General HospitalHuishu Yuan - Peking UniversityZilong Zeng - Beijing Normal UniversityHaibo Zhang - Beijing Normal UniversityXi Zhang - Chinese PLA General HospitalGai Zhao - Beijing Normal UniversityYanting Zheng - First Affiliated Hospital of Guangzhou University of Chinese MedicineSuyu Zhong - Beijing Academy of Artificial IntelligenceMichael WeinerPaul AisenRonald PetersenClifford R. JackWilliam JagustJohn Q. TrojanowkiArthur W. TogaLaurel BeckettRobert C. GreenAndrew J. SaykinJohn MorrisLeslie M. ShawEnchi LiuTom MontineRonald G. ThomasMichael DonohueSarah WalterDevon GessertTamie SatherGus JiminezDanielle HarveyMatthew BernsteinNick FoxPaul ThompsonNorbert SchuffCharles DeCArliBret BorowskiJeff GunterMatt SenjemPrashanthi VemuriDavid JonesKejal KantarciChad WardRobert A. KoeppeNorm FosterEric M. ReimanKewei ChenChet MathisSusan LandauNigel J. CairnsErin HouseholderLisa Taylor ReinwaldVirginia LeeMagdalena KoreckaMichal FigurskiKaren CrawfordScott NeuTatiana M. ForoudSteven PotkinLi ShenFaber KelleySungeun KimKwangsik NhoZaven KachaturianRichard FrankPeter J. SnyderSusan MolchanJeffrey KayeJoseph QuinnBetty LindRaina CarterSara DolenLon S. SchneiderSonia PawluczykMauricio BecceraLiberty TeodoroBryan M. SpannJames BrewerHelen VanderswagAdam FleisherJudith L. HeidebrinkJoanne L. LordSara S. MasonColleen S. AlbersDavid KnopmanKris JohnsonRachelle S. DoodyJavier Villanueva MeyerMunir ChowdhurySusan RountreeMimi DangYaakov SternLawrence S. HonigKaren L. BellBeau AncesJohn C. MorrisMaria CarrollSue LeonMark A. MintunStacy SchneiderAngela OliverRandall GriffithDavid ClarkDavid GeldmacherJohn BrockingtonErik RobersonHillel GrossmanEffie MitsisLeyla deToledo-MorrellRaj C. ShahRanjan DuaraDaniel VaronMaria T. GreigPeggy RobertsMarilyn AlbertChiadi OnyikeDaniel D’AgostinoStephanie KielbJames E. GalvinDana M. PogorelecBrittany CerboneChristina A. MichelHenry RusinekMony J. de LeonLidia GlodzikSusan De SantiP. Murali DoraiswamyJeffrey R. PetrellaTerence Z. WongSteven E. ArnoldJason H. KarlawishDavid WolkCharles D. SmithGreg JichaPeter HardyPartha SinhaElizabeth OatesGary ConradOscar L. LopezMaryAnn OakleyDonna M. SimpsonAnton P. PorsteinssonBonnie S. GoldsteinKim MartinKelly M. MakinoM. Saleem IsmailConnie BrandRuth A. MulnardGaby ThaiCatherine McAdams OrtizKyle WomackDana MathewsMary QuicenoRamon Diaz ArrastiaRichard KingMyron WeinerKristen Martin CookMichael DeVousAllan I. LeveyJames J. LahJanet S. CellarJeffrey M. BurnsHeather S. AndersonRussell H. SwerdlowLiana ApostolovaKathleen TingusEllen WooDaniel H.S. SilvermanPo H. LuGeorge BartzokisNeill R. Graff RadfordFrancine ParfittTracy KendallHeather JohnsonMartin R. FarlowAnn Marie HakeBrandy R. MatthewsScott HerringCynthia HuntChristopher H. van DyckRichard E. CarsonMartha G. MacAvoyHoward ChertkowHoward BergmanChris HoseinSandra BlackBojana StefanovicCurtis CaldwellGing Yuek Robin HsiungHoward FeldmanBenita MudgeMichele Assaly PastAndrew KerteszJohn RogersDick TrostCharles BernickDonna MunicDiana KerwinMarek Marsel MesulamKristine LipowskiChuang Kuo WuNancy JohnsonCarl SadowskyWalter MartinezTeresa VillenaRaymond Scott TurnerKathleen JohnsonBrigid ReynoldsReisa A. SperlingKeith A. JohnsonGad MarshallMeghan FreyJerome YesavageJoy L. TaylorBarton LaneAllyson RosenJared TinklenbergMarwan N. SabbaghChristine M. BeldenSandra A. JacobsonSherye A. SirrelNeil KowallRonald KillianyAndrew E. BudsonAlexander NorbashPatricia Lynn JohnsonThomas O. ObisesanSaba WoldayJoanne AllardAlan LernerPaula OgrockiLeon HudsonEvan FletcherOwen CarmichaelJohn OlichneySmita KitturMichael BorrieT.Y. LeeRob BarthaRobert B. SantulliTamar J. KitzmillerEben S. SchwartzKaycee M. SinkJeff D. WilliamsonPradeep GargFranklin WatkinsBrian R. OttHenry QuerfurthGeoffrey TremontStephen SallowayPaul MalloyStephen CorreiaHoward J. RosenBruce L. MillerJacobo MintzerKenneth SpicerDavid BachmanElizabeth FingerStephen PasternakIrina RachinskyDick DrostNunzio PomaraRaymundo HernandoAntero SarraelSusan K. SchultzLaura L. Boles PontoHyungsub ShimKaren Elizabeth SmithNorman RelkinGloria ChaingLisa RaudinAmanda SmithKristin FargherBalebail Ashok RajYuying ZhouAlzheimer’s Disease Neuroimaging Initiative (ADNI)
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.113(19), pp.3275-3295.e11
- DOI
- 10.1016/j.neuron.2025.06.018
- PMID
- 40706587
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc; CAMBRIDGE
- Grant note
- National Natural Science Foundation of China: 82021004, 82327807, 824B2051, T24B2012, 31521063, 31221003, 82071998, T2325006, 82202245, 81971690, 32130045, 81571062, 82172018, 81471120, 61633018, 81901101, 81400890, 81920108019, 82330058, 91649117, 81771344, 81471251, 82430063, 32471096, 82102131, 81425013 Brain Science and Brain-Inspired Intelligence Technology: 2021ZD0200500, 2022ZD0211500 Changjiang Scholar Professorship Award: T2015027 Beijing Natural Science Foundation: JQ23033 Beijing Brain Initiative of Beijing Municipal Science & Technology Commission: Z181100001518003 Fund of Shenzhen Institute for Neuroscience ResearchScience and Technology Plan Project of Guangzhou: 2018-1002-SF-0442 Guangzhou Key Laboratory: 09002344 Key R&D Program of Sichuan Province: 2023YFS0076
This work was supported by grants from the National Natural Science Foundation of China (82021004 and 82327807 to Y. He, 824B2051 to X. Liang, and T24B2012 to L.S.), the scientific and technological innovation 2030-the major project of the Brain Science and Brain-Inspired Intelligence Technology (2021ZD0200500 to Q.D. and 2022ZD0211500 to M.X.), the Changjiang Scholar Professorship Award (T2015027 to Y. He), the Beijing Natural Science Foundation (JQ23033 to M.X.), the National Natural Science Foundation of China (31521063 and 31221003 to Q.D.; 82071998 to M.X.; T2325006 to G. G.; 82202245 to Q. Li; 81971690 to X. Liao; 32130045 to S. Qin; 81571062 and 82172018 to Yong Liu; 81471120 to X.Z.; 61633018 to Y. Han; 81901101 to P.W.; 81400890 to D. Wang; 81920108019, 82330058, 91649117, 81771344, and 81471251 to S. Qiu; 82430063 to C.Y.; 32471096 to J.Q.; 82102131 to Y.X.; and 81425013 to W.Q.), the Beijing Brain Initiative of Beijing Municipal Science & Technology Commission (Z181100001518003 to S. Tao), the Fund of Shenzhen Institute for Neuroscience Research (S. Tao), the Science and Technology Plan Project of Guangzhou (2018-1002-SF-0442 to S. Qiu), the Guangzhou Key Laboratory (09002344 to S. Qiu), and the Key R&D Program of Sichuan Province (2023YFS0076 to T.C.). We are grateful to all the data contributors.
- Language
- English
- Electronic publication date
- 07/23/2025
- Date published
- 10/2025
- Academic Unit
- Neurology; Radiology; Psychiatry
- Record Identifier
- 9984927081202771
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