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Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome
Journal article   Open access   Peer reviewed

Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome

Yashant Aswani, Hemangini Thakkar and Priya Hira
The Indian journal of radiology & imaging, Vol.26(4), pp.482-486
01/01/2016
DOI: 10.4103/0971-3026.195781
PMCID: PMC5201079
PMID: 28104943
url
https://doi.org/10.4103/0971-3026.195781View
Published (Version of record) Open Access

Abstract

Choriocarcinoma is a human chorionic gonadotrophin (HCG)-secreting tumor that comprises vascular channels. It has a tendency for widespread metastasis, common sites for which include the lung, vagina, brain, liver, bone, intestine, and kidney. We describe a 30-year-old female who presented with hepatitis-like features and bilateral diminution of vision, and subsequently developed hemothorax and hemoperitoneum—all rare and seemingly unrelated manifestations which were finally attributable to metastases from gestational choriocarcinoma. To further complicate the clinical scenario, the serum HCG of the patient was mildly raised (due to a phenomenon called hook effect). Subsequently, the patient developed disseminated intravascular coagulation and succumbed to her illness. In this report, we discuss the imaging findings of choriocarcinoma, its potential sites of metastases, and the hook effect.
 Choriocarcinoma chorionic gonadotrophin color Doppler hemoperitoneum hemothorax ultrasonography Women Imaging

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