Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital

Ana Carolina Ramos; Rodrigo Cayô; Cecilia Godoy Carvalhaes; Thomas Jové; Greice Pereira da Silva; Fernanda Maciel Paschoin Sancho; Thomas Chagas-Neto; Eduardo Alexandrino Servolo Medeiros; Ana Cristina Gales

doi:10.1128/AAC.01321-17

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Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital

Journal article

Peer reviewed

Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital

Ana Carolina Ramos, Rodrigo Cayô, Cecilia Godoy Carvalhaes, Thomas Jové, Greice Pereira da Silva, Fernanda Maciel Paschoin Sancho, Thomas Chagas-Neto, Eduardo Alexandrino Servolo Medeiros and Ana Cristina Gales

Antimicrobial agents and chemotherapy, Vol.62(2), e01321-17

02/2018

DOI: 10.1128/AAC.01321-17

PMID: 29158274

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Abstract

This study aimed to characterize multidrug-resistant clones carrying a novel class 1 integron-borne In was inserted into a large conjugative plasmid that also carried The production of carbapenemases in that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.

Anti-Bacterial Agents - pharmacology

beta-Lactamases - genetics

beta-Lactamases - metabolism

Brazil - epidemiology

Carbapenems - pharmacology

Clone Cells

Drug Resistance, Multiple, Bacterial - genetics

Gene Expression Regulation, Bacterial

Humans

Integrons

Microbial Sensitivity Tests

Plasmids - chemistry

Plasmids - metabolism

Polymyxins - pharmacology

Proteus Infections - drug therapy

Proteus Infections - epidemiology

Proteus Infections - microbiology

Proteus Infections - transmission

Proteus mirabilis - drug effects

Proteus mirabilis - enzymology

Proteus mirabilis - genetics

Proteus mirabilis - isolation & purification

Tertiary Care Centers

Tigecycline - pharmacology

Details

Title: Subtitle: Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla IMP-1 in a Tertiary Hospital
Creators: Ana Carolina Ramos - Universidade Federal de São Paulo
Rodrigo Cayô - Universidade Federal de São Paulo
Cecilia Godoy Carvalhaes - Universidade Federal de São Paulo
Thomas Jové - Université de Limoges
Greice Pereira da Silva - Associação Paulista para o Desenvolvimento da Medicina
Fernanda Maciel Paschoin Sancho - Associação Paulista para o Desenvolvimento da Medicina
Thomas Chagas-Neto - Hospital São Paulo
Eduardo Alexandrino Servolo Medeiros - Universidade Federal de São Paulo
Ana Cristina Gales - Universidade Federal de São Paulo
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.62(2), e01321-17
DOI: 10.1128/AAC.01321-17
PMID: 29158274
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Grant note: DOI: 10.13039/501100003593, name: MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico, award: 305535/2014-5; DOI: 10.13039/501100002322, name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; DOI: 10.13039/501100002322, name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, award: PNPD 20131991
Language: English
Date published: 02/2018
Academic Unit: Pathology
Record Identifier: 9984183989602771

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