Journal article
Disseminins and Spiciferone Analogues: Polyketide-Derived Metabolites from a Fungicolous Isolate of Pestalotiopsis disseminata
Journal of natural products (Washington, D.C.), Vol.79(3), pp.523-530
03/25/2016
DOI: 10.1021/acs.jnatprod.5b00907
PMID: 26641923
Abstract
Seven new polyketide metabolites (disseminins A-E, 1-5, and spiciferones D and E, 7 and 8) were obtained from cultures of a fungicolous isolate of Pestalotiopsis disseminata (NRRL 62562), together with a related compound (6) previously known only as a semisynthetic product. Structures were determined mainly by analysis of HRMS and NMR data. Biogenetically related compounds 1 and 2 possess uncommon bis-tetrahydrofuran and dioxabicyclo[3.2.1]octane ring systems, respectively. X-ray crystallographic analysis of the p-bromobenzoate derivative of 1 confirmed the structure and enabled assignment of its absolute configuration.
Details
- Title: Subtitle
- Disseminins and Spiciferone Analogues: Polyketide-Derived Metabolites from a Fungicolous Isolate of Pestalotiopsis disseminata
- Creators
- In Hyun Hwang - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United StatesDale C Swenson - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United StatesJames B Gloer - Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United StatesDonald T Wicklow - Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA , Peoria, Illinois 61604, United States
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.79(3), pp.523-530
- Publisher
- United States
- DOI
- 10.1021/acs.jnatprod.5b00907
- PMID
- 26641923
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Grant note
- S10 RR025500 / NCRR NIH HHS S10 RR023384 / NCRR NIH HHS
- Language
- English
- Date published
- 03/25/2016
- Academic Unit
- Chemistry
- Record Identifier
- 9983985964502771
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