Dissociable roles of the dorsolateral and ventromedial prefrontal cortex in human categorization

Matthew B Broschard; Brandon M Turner; Daniel Tranel; John H Freeman

doi:10.1523/JNEUROSCI.2343-23.2024

Models of human categorization predict the prefrontal cortex (PFC) serves a central role in category learning. The dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) have been implicated in categorization; however, it is unclear whether both are critical for categorization and whether they support unique functions. We administered three categorization tasks to patients with PFC lesions (mean age = 69.6 years; 5 men, 5 women) to examine how prefrontal subregions contribute to categorization. These included a rule-based (RB) task that was solved via a unidimensional rule, an information integration (II) task that was solved by combining information from two stimulus dimensions, and a deterministic/probabilistic (DP) task with stimulus features that had varying amounts of category-predictive information. Compared to healthy comparison participants, both patient groups had impaired performance. Impairments in the dlPFC patients were largest during the RB task, whereas impairments in the vmPFC patients were largest during the DP task. A hierarchical model was fit to the participants' data to assess learning deficits in the patient groups. PFC damage was correlated with a regularization term that limited updates to attention after each trial. Our results suggest that the PFC, as a whole, is important for learning to orient attention to relevant stimulus information. The dlPFC may be especially important for rule-based learning, whereas the vmPFC may be important for focusing attention on deterministic (highly diagnostic) features and ignoring less predictive features. These results support overarching functions of the dlPFC in executive functioning and the vmPFC in value-based decision making.Significance Statement Category learning creates flexible memory representations that easily generalize to novel situations. Although it is generally established that the prefrontal cortex is central to categorization, it is unclear how different prefrontal subregions contribute to learning. Separate literatures have implicated both the dorsolateral prefrontal cortex (dlPFC) and the ventromedial prefrontal cortex (vmPFC) in categorization, but there has been little effort to bridge these literatures. The current study is the first to examine categorization in patients with lesions centered in the dlPFC and vmPFC. We found that, as a whole, the PFC orients attention to relevant stimulus information. The dlPFC is important for rule-based learning, whereas the vmPFC is important for focusing attention on highly diagnostic features and ignoring less predictive features.Models of human categorization predict the prefrontal cortex (PFC) serves a central role in category learning. The dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) have been implicated in categorization; however, it is unclear whether both are critical for categorization and whether they support unique functions. We administered three categorization tasks to patients with PFC lesions (mean age = 69.6 years; 5 men, 5 women) to examine how prefrontal subregions contribute to categorization. These included a rule-based (RB) task that was solved via a unidimensional rule, an information integration (II) task that was solved by combining information from two stimulus dimensions, and a deterministic/probabilistic (DP) task with stimulus features that had varying amounts of category-predictive information. Compared to healthy comparison participants, both patient groups had impaired performance. Impairments in the dlPFC patients were largest during the RB task, whereas impairments in the vmPFC patients were largest during the DP task. A hierarchical model was fit to the participants' data to assess learning deficits in the patient groups. PFC damage was correlated with a regularization term that limited updates to attention after each trial. Our results suggest that the PFC, as a whole, is important for learning to orient attention to relevant stimulus information. The dlPFC may be especially important for rule-based learning, whereas the vmPFC may be important for focusing attention on deterministic (highly diagnostic) features and ignoring less predictive features. These results support overarching functions of the dlPFC in executive functioning and the vmPFC in value-based decision making.Significance Statement Category learning creates flexible memory representations that easily generalize to novel situations. Although it is generally established that the prefrontal cortex is central to categorization, it is unclear how different prefrontal subregions contribute to learning. Separate literatures have implicated both the dorsolateral prefrontal cortex (dlPFC) and the ventromedial prefrontal cortex (vmPFC) in categorization, but there has been little effort to bridge these literatures. The current study is the first to examine categorization in patients with lesions centered in the dlPFC and vmPFC. We found that, as a whole, the PFC orients attention to relevant stimulus information. The dlPFC is important for rule-based learning, whereas the vmPFC is important for focusing attention on highly diagnostic features and ignoring less predictive features.

Dissociable roles of the dorsolateral and ventromedial prefrontal cortex in human categorization

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