Journal article
Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity
Science (American Association for the Advancement of Science), Vol.270(5233), pp.99-102
10/06/1995
DOI: 10.1126/science.270.5233.99
PMID: 7569957
Abstract
Furosemide, a chloride cotransport inhibitor, reversibly blocked synchronized burst discharges in hippocampal slices without reducing the pyramidal cell response to single electrical stimuli. Images of the intrinsic optical signal acquired during these slice experiments indicated that furosemide coincidentally blocked changes in extracellular space. In urethane-anesthetized rats, systemically injected furosemide blocked kainic acid-induced electrical discharges recorded from cortex. These results suggest that (i) neuronal synchronization involved in epileptiform activity can be dissociated from synaptic excitability; (ii) nonsynaptic mechanisms, possibly associated with furosemide-sensitive cell volume regulation, may be critical for synchronization of neuronal activity; and (iii) agents that affect extracellular volume may have clinical utility as antiepileptic drugs.
Details
- Title: Subtitle
- Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity
- Creators
- Daryl W. Hochman - University of WashingtonScott C. Baraban - University of WashingtonJames W. M. Owens - University of WashingtonPhilip A. Schwartzkroin - University of Washington
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.270(5233), pp.99-102
- DOI
- 10.1126/science.270.5233.99
- PMID
- 7569957
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Number of pages
- 4
- Language
- English
- Date published
- 10/06/1995
- Academic Unit
- Stead Family Department of Pediatrics; Neurology (Pediatrics)
- Record Identifier
- 9984701556802771
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