Journal article
Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum
Clinical psychological science
02/02/2026
DOI: 10.1177/21677026251414032
PMCID: PMC13035350
PMID: 41918945
Abstract
The Hierarchical Taxonomy of Psychopathology (HiTOP) provides a dimensional framework for connecting psychological disorders to neural systems/processes. We examined how neurophysiological measures of cognitive-attentional (oddball P300) and perceptual-emotional processing (fear-face N170/P200) relate to dimensions of the HiTOP externalizing spectrum. Employing 666 community participants, we fit a model in which antagonistic externalizing and substance-problems subfactors, defined via symptom and questionnaire-scale measures, loaded with a disinhibitory trait scale onto a higher-order externalizing factor. Hierarchical regression was used to evaluate how much observed relations of each neural measure with the two subfactors reflected their unique variance versus their covariance (reflected in the general factor). P300's relations were fully accounted for by the general factor, suggesting that impaired cognitive processing characterizes broad risk for externalizing problems. Neural indicators of sensitivity to others' distress (N170, P200) were uniquely related to antagonistic externalizing. Findings highlight the HiTOP framework's potential to advance biobehavioral understanding of psychopathology.
Details
- Title: Subtitle
- Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum
- Creators
- Christopher J. Patrick - Florida State UniversityPablo Ribes-Guardiola - Universitat de ValènciaBruce D. Bartholow - University of IowaAlexander M. Kallen - Florida State UniversityEmily R. Perkins - University of PennsylvaniaRobert F. Krueger - University of MinnesotaColin G. Deyoung - University of MinnesotaRoman Kotov - Stony Brook UniversityRita Pasion - Universidade LusófonaSylia Wilson - University of MinnesotaJames R. Yancey - Mental Illness Research, Education and Clinical CentersSarah J. Brislin - Rutgers, The State University of New JerseySally L. Cole - Florida State UniversityDavid C. Cicero - University of North TexasChristopher Conway - Fordham UniversityMiriam K. Forbes - Macquarie UniversityJeremy Harper - University of MinnesotaBrian M. Hicks - University of MichiganChristopher J. Hopwood - University of ZurichWilliam G. Iacono - University of MinnesotaKatherine G. Jonas - Stony Brook UniversityAntonia Kaczkurkin - Vanderbilt UniversityRobert D. Latzman - Takeda (Japan)Kristian E. Markon - University of MinnesotaElizabeth A. Martin - University of California, IrvineGiorgia Michelini - Queen Mary University of LondonLindsay D. Nelson - Medical College of WisconsinJonathan Schaefer - Vanderbilt UniversityMartin Sellbom - Monash UniversityNoah C. Venables - University of MinnesotaIrwin D. Waldman - Emory UniversityAidan G. C. Wright - University of MichiganDavid H. Zald - Rutgers, The State University of New JerseyKeanan J. Joyner - University of California, Berkeley
- Resource Type
- Journal article
- Publication Details
- Clinical psychological science
- DOI
- 10.1177/21677026251414032
- PMID
- 41918945
- PMCID
- PMC13035350
- ISSN
- 2167-7026
- eISSN
- 2167-7034
- Publisher
- Sage
- Number of pages
- 22
- Grant note
- MH072850; MH089727; AA030728; AA030914; AG051426 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Lusofona University's Cooperativa de Formacao e Animacao Cultural Portugal's Fundacao para a Ciencia e a Tecnologia, I.P.
- Language
- English
- Electronic publication date
- 02/02/2026
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9985139296202771
Metrics
1 Record Views