Journal article
Distinct Neural Substrates of Duration-Based and Beat-Based Auditory Timing
The Journal of neuroscience, Vol.31(10), pp.3805-3812
03/09/2011
DOI: 10.1523/JNEUROSCI.5561-10.2011
PMCID: PMC3074096
PMID: 21389235
Abstract
Research on interval timing strongly implicates the cerebellum and the basal ganglia as part of the timing network of the brain. Here we tested the hypothesis that the brain uses differential timing mechanisms and networks-specifically, that the cerebellum subserves the perception of the absolute duration of time intervals, whereas the basal ganglia mediate perception of time intervals relative to a regular beat. In a functional magnetic resonance imaging experiment, we asked human subjects to judge the difference in duration of two successive time intervals as a function of the preceding context of an irregular sequence of clicks (where the task relies on encoding the absolute duration of time intervals) or a regular sequence of clicks (where the regular beat provides an extra cue for relative timing). We found significant activations in an olivocerebellar network comprising the inferior olive, vermis, and deep cerebellar nuclei including the dentate nucleus during absolute, duration-based timing and a striato-thalamo-cortical network comprising the putamen, caudate nucleus, thalamus, supplementary motor area, premotor cortex, and dorsolateral prefrontal cortex during relative, beat-based timing. Our results support two distinct timing mechanisms and underlying subsystems: first, a network comprising the inferior olive and the cerebellum that acts as a precision clock to mediate absolute, duration-based timing, and second, a distinct network for relative, beat-based timing incorporating a striato-thalamo-cortical network.
Details
- Title: Subtitle
- Distinct Neural Substrates of Duration-Based and Beat-Based Auditory Timing
- Creators
- Sundeep Teki - Wellcome Centre for Human NeuroimagingManon Grube - Newcastle UniversitySukhbinder Kumar - Wellcome Centre for Human NeuroimagingTimothy D. Griffiths - Wellcome Centre for Human Neuroimaging
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.31(10), pp.3805-3812
- DOI
- 10.1523/JNEUROSCI.5561-10.2011
- PMID
- 21389235
- PMCID
- PMC3074096
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- Soc Neuroscience
- Number of pages
- 8
- Grant note
- Wellcome Trust, UK; Wellcome Trust
- Language
- English
- Date published
- 03/09/2011
- Academic Unit
- Psychological and Brain Sciences; Neurosurgery
- Record Identifier
- 9984303901302771
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