Journal article
Distinct aging-vulnerable and -resilient trajectories of specific motor circuit functions in oxidation- and temperature-stressed Drosophila
eNeuro, Vol.9(1), p.ENEURO.0443-21.2021
12/07/2021
DOI: 10.1523/ENEURO.0443-21.2021
PMCID: PMC8805199
PMID: 34876473
Abstract
In Drosophila, molecular pathways affecting longevity have been extensively studied. However, corresponding neurophysiological changes underlying aging-related functional and behavioral deteriorations remain to be fully explored. We examined different motor circuits in Drosophila across the life span and uncovered distinctive age-resilient and age-vulnerable trajectories in their established functional properties. In the giant fiber (GF) and downstream circuit elements responsible for the jump-and-flight escape reflex, we observed relatively mild deterioration toward the end of the life span. In contrast, more substantial age-dependent modifications were seen in the plasticity of GF afferent processing, specifically in use dependence and habituation properties. In addition, there were profound changes in different afferent circuits that drive flight motoneuron activities, including flight pattern generation and seizure spike discharges evoked by electroconvulsive stimulation. Importantly, in high-temperature (HT)-reared flies (29°C), the general trends in these age-dependent trajectories were largely maintained, albeit over a compressed time scale, lending support for the common practice of HT rearing for expediting Drosophila aging studies. We discovered that shortened life spans in Cu/Zn superoxide dismutase (Sod) mutant flies were accompanied by altered aging trajectories in motor circuit properties distinct from those in HT-reared flies, highlighting differential effects of oxidative versus temperature stressors. This work helps to identify several age-vulnerable neurophysiological parameters that may serve as quantitative indicators for assessing genetic and environmental influences on aging progression in Drosophila.
Keywords: escape circuit; flight; habituation; oxidative stress; seizure; temperature stress.
Details
- Title: Subtitle
- Distinct aging-vulnerable and -resilient trajectories of specific motor circuit functions in oxidation- and temperature-stressed Drosophila
- Creators
- Atulya IyengarHongyu RuanChun-Fang Wu
- Resource Type
- Journal article
- Publication Details
- eNeuro, Vol.9(1), p.ENEURO.0443-21.2021
- DOI
- 10.1523/ENEURO.0443-21.2021
- PMID
- 34876473
- PMCID
- PMC8805199
- NLM abbreviation
- eNeuro
- ISSN
- 2373-2822
- eISSN
- 2373-2822
- Grant note
- DOI: 10.13039/100000057, name: HHS | NIH | National Institute of General Medical Sciences, award: GM088804; DOI: 10.13039/100000049, name: HHS | NIH | National Institute on Aging, award: AG047612, AG051513; DOI: 10.13039/100000065, name: HHS | NIH | National Institute of Neurological Disorders and Stroke, award: NS082001; name: Iowa Neuroscience Institute
- Language
- English
- Date published
- 12/07/2021
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984201450602771
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