Journal article
Distinct cognitive profiles of cortical and subcortical dementia in advanced illness
Neurology, Vol.45(5), pp.951-956
1995
DOI: 10.1212/WNL.45.5.951
PMID: 7746413
Abstract
We administered the Mattis Dementia Rating Scale (DRS) to 120 patients to evaluate the effect of dementia severity on distinct cognitive profiles. Sixty patients with Huntington's disease (HD) and 60 patients with Alzheimer's disease (AD) were separated by dementia severity into three groups: mildly demented (DRS mean total = 129), moderately demented (DRS mean total = 117), and severely demented (DRS mean total = 102). At all levels of dementia severity, HD patients demonstrated greater impairment than AD patients on the Initiation/Perseveration sub-scale, whereas AD patients demonstrated greater impairment than HD patients on the Memory subscale. At moderate and severe levels of dementia, HD patients demonstrated an additional impairment in constructional praxis. These profile differences were independent of dementia severity and continued to differentiate between so-called cortical and subcortical dernentias in later stages of dementia severity.
Details
- Title: Subtitle
- Distinct cognitive profiles of cortical and subcortical dementia in advanced illness
- Creators
- J. S PAULSEN - Univ. California San Diego school medicine, San Diego CA 92161, United StatesN BUTTERS - Univ. California San Diego school medicine, San Diego CA 92161, United StatesJ. R SADEK - Univ. California San Diego school medicine, San Diego CA 92161, United StatesS. A JOHNSON - Univ. California San Diego school medicine, San Diego CA 92161, United StatesD. P SALMON - Univ. California San Diego school medicine, San Diego CA 92161, United StatesN. R SWERDLOW - Univ. California San Diego school medicine, San Diego CA 92161, United StatesM. R SWENSON - Univ. California San Diego school medicine, San Diego CA 92161, United States
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.45(5), pp.951-956
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1212/WNL.45.5.951
- PMID
- 7746413
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 1995
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083999602771
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