Journal article
Distinct critical cerebellar subregions for components of verbal working memory
Neuropsychologia, Vol.50(1), pp.189-197
01/01/2012
DOI: 10.1016/j.neuropsychologia.2011.11.017
PMCID: PMC4040406
PMID: 22133495
Abstract
A role for the cerebellum in cognition has been proposed based on studies suggesting a profile of cognitive deficits due to cerebellar stroke. Such studies are limited in the determination of the detailed organisation of cerebellar subregions that are critical for different aspects of cognition. In this study we examined the correlation between cognitive performance and cerebellar integrity in a specific degeneration of the cerebellar cortex: Spinocerebellar Ataxia type 6 (SCA6). The results demonstrate a critical relationship between verbal working memory and grey matter density in superior (bilateral lobules VI and crus I of lobule VII) and inferior (bilateral lobules VIIIa and VIIb, and right lobule IX) parts of the cerebellum. We demonstrate that distinct cerebellar regions subserve different components of the prevalent psychological model for verbal working memory based on a phonological loop. The work confirms the involvement of the cerebellum in verbal working memory and defines specific subsystems for this within the cerebellum. (C) 2011 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Distinct critical cerebellar subregions for components of verbal working memory
- Creators
- Freya E. Cooper - Newcastle UniversityManon Grube - Newcastle UniversityKatharina Von Kriegstein - Max Planck SocietySukhbinder Kumar - Newcastle UniversityPhilip English - Newcastle UniversityThomas P. Kelly - Newcastle UniversityPatrick F. Chinnery - Newcastle UniversityTimothy D. Griffiths - Newcastle University
- Resource Type
- Journal article
- Publication Details
- Neuropsychologia, Vol.50(1), pp.189-197
- Publisher
- Elsevier
- DOI
- 10.1016/j.neuropsychologia.2011.11.017
- PMID
- 22133495
- PMCID
- PMC4040406
- ISSN
- 0028-3932
- eISSN
- 1873-3514
- Number of pages
- 9
- Grant note
- NF-SI-0509-10011 / National Institute for Health Research; National Institute for Health Research (NIHR) Ataxia UK Welcome Trust; Wellcome Trust Max-Planck Society; Max Planck Society; Foundation CELLEX
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Psychological and Brain Sciences; Neurosurgery
- Record Identifier
- 9984304030502771
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