Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations

Atsushi Ueda; Chun-Fang Wu

doi:10.1523/JNEUROSCI.0862-06.2006

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Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations

Journal article

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Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations

Atsushi Ueda and Chun-Fang Wu

The Journal of neuroscience, Vol.26(23), pp.6238-6248

06/07/2006

DOI: 10.1523/JNEUROSCI.0862-06.2006

PMCID: PMC6675186

PMID: 16763031

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Abstract

Regulation of synaptic efficacy by nerve terminal excitability has not been extensively studied. We performed genetic and pharmacological dissections for presynaptic actions of K+ channels in Drosophila neuromuscular transmission by using electrophysiological and optical imaging techniques. Current understanding of the roles of the Shab IK channel and its mammalian Kv2 counterparts is relatively poor, as compared with that for Shaker IA channels and their Kv1 homologues. Our results revealed the striking effect of Shab mutations during high-frequency synaptic activity, as well as a functional division in synaptic regulation between the Shaker and Shab channels. Shaker channels control the basal level of release, indicated by a response to single nerve stimulation, whereas Shab channels regulate repetitive synaptic activities. These observations highlight the crucial control of nerve terminal excitability by Shaker and Shab channels to confer temporal patterns of synaptic transmission and suggest the potential participation of these channels, along with the transmitter release machinery, in activity-dependent synaptic plasticity.

Shab Potassium Channels - genetics

Motor Activity - physiology

Motor Neurons - physiology

Electric Stimulation

Synaptic Transmission - physiology

Shaker Superfamily of Potassium Channels - genetics

Synapses - physiology

Neurotransmitter Agents - metabolism

Electrophysiology

Axons - physiology

Quinidine - pharmacology

Shab Potassium Channels - physiology

Shaker Superfamily of Potassium Channels - physiology

Drosophila Proteins - physiology

Animals

Nerve Endings - physiology

Drosophila melanogaster - growth & development

Drosophila Proteins - genetics

Larva - physiology

Mutation

Action Potentials - drug effects

Neuromuscular Junction - physiology

Details

Title: Subtitle: Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations
Creators: Atsushi Ueda - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
Chun-Fang Wu
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.26(23), pp.6238-6248
DOI: 10.1523/JNEUROSCI.0862-06.2006
PMID: 16763031
PMCID: PMC6675186
NLM abbreviation: J Neurosci
ISSN: 0270-6474
eISSN: 1529-2401
Publisher: United States
Grant note: NS26528 / NINDS NIH HHS HD18577 / NICHD NIH HHS
Language: English
Date published: 06/07/2006
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984070008202771

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