Journal article
Distinct gating modes determine the biphasic relaxation of NMDA receptor currents
Nature neuroscience, Vol.11(12), pp.1373-1375
12/2008
DOI: 10.1038/nn.2214
PMCID: PMC2587015
PMID: 18953348
Abstract
Following brief stimulation, macroscopic NMDA receptor currents decay with biphasic kinetics that is believed to reflect glutamate dissociation and receptor desensitization. We found that the fast and slow decay components arise from the simultaneous deactivation of receptor populations that gate with short and long openings, respectively. Because individual receptors switched infrequently between gating modes, the relaxation time course was largely determined by the proportion of channels in each gating mode at the time of stimulation.
Details
- Title: Subtitle
- Distinct gating modes determine the biphasic relaxation of NMDA receptor currents
- Creators
- Wei Zhang - Department of Pharmacology, Yale University School of MedicineJames R Howe - Department of Pharmacology, Yale University School of MedicineGabriela K Popescu - Departments of Biochemistry and Anesthesiology, University at Buffalo, SUNY
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.11(12), pp.1373-1375
- DOI
- 10.1038/nn.2214
- PMID
- 18953348
- PMCID
- PMC2587015
- NLM abbreviation
- Nat Neurosci
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 12/2008
- Academic Unit
- Surgery
- Record Identifier
- 9984051576302771
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