Journal article
Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections
Vaccine, Vol.25(35), pp.6458-6473
2007
DOI: 10.1016/j.vaccine.2007.06.035
PMID: 17651872
Abstract
Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents.
Details
- Title: Subtitle
- Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections
- Creators
- Christina A Scherer - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesCharles L Magness - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesKathryn V Steiger - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesNicholas D Poitinger - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesChristine M Caputo - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesDouglas G Miner - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United StatesPatricia L Winokur - Departments of Research and Internal Medicine, Iowa City VA Medical Center and the University of Iowa, Iowa City, IA 52242, United StatesDonna Klinzman - Departments of Research and Internal Medicine, Iowa City VA Medical Center and the University of Iowa, Iowa City, IA 52242, United StatesJanice McKee - Hall Health Medical Center, University of Washington, Seattle, WA 98195, United StatesChristine Pilar - Madrona Medical Group, 4545 Cordata Parkway, Bellingham, WA 98226, United StatesPatricia A Ward - Madrona Medical Group, 4545 Cordata Parkway, Bellingham, WA 98226, United StatesMartha H Gillham - Madrona Medical Group, 4545 Cordata Parkway, Bellingham, WA 98226, United StatesN. Jean Haulman - Hall Health Medical Center, University of Washington, Seattle, WA 98195, United StatesJack T Stapleton - Departments of Research and Internal Medicine, Iowa City VA Medical Center and the University of Iowa, Iowa City, IA 52242, United StatesShawn P Iadonato - Illumigen Biosciences Inc., 201 Elliott Ave. W., Suite 500, Seattle, WA 98119, United States
- Resource Type
- Journal article
- Publication Details
- Vaccine, Vol.25(35), pp.6458-6473
- DOI
- 10.1016/j.vaccine.2007.06.035
- PMID
- 17651872
- NLM abbreviation
- Vaccine
- ISSN
- 0264-410X
- eISSN
- 1873-2518
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2007
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094537502771
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