Journal article
Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations
Annals of diagnostic pathology, Vol.16(1), pp.16-20
01/2012
DOI: 10.1016/j.anndiagpath.2011.07.005
PMID: 22050963
Abstract
FMS-like tyrosine kinase 3 (FLT3) mutation in T lymphoblastic leukemia/lymphoma (T-LL) is rare (∼4%) and reported only in cases with CD117 expression. This study aimed to identify the immunophenotypic features that may predict FLT3 mutations. We report 3 (43%) of 7 CD117+ T-LL cases harboring FLT3-internal tandem duplication mutation. Compared with 4 FLT3-unmutated cases, all 3 FLT3-mutated cases had a distinct immunophenotype (CD1a−/CD2+/CD7+/CD34+/CD117uniform+/Tdt+) corresponding to the stage of earliest thymic T-cell progenitors possessing myeloid lineage potential. Indeed, all FLT3-mutated T-LL cases expressed myeloperoxidase on a very small subset of blasts and, thus, may be further considered a mixed phenotype acute leukemia, T/myeloid, by the 2008 World Health Organization classification scheme. We conclude that this unique immunophenotype (CD1a−/CD2+/CD7+/CD34+/CD117+/Tdt+) is a better predictor of FLT3 mutation than sole CD117 expression.
Details
- Title: Subtitle
- Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations
- Creators
- Charles M Zaremba - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USADwight Oliver - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USAMaryellen Cavalier - Department of Pediatric Hematology and Oncology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USAFranklin Fuda - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USANitin J Karandikar - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USAWeina Chen - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
- Resource Type
- Journal article
- Publication Details
- Annals of diagnostic pathology, Vol.16(1), pp.16-20
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.anndiagpath.2011.07.005
- PMID
- 22050963
- ISSN
- 1092-9134
- eISSN
- 1532-8198
- Language
- English
- Date published
- 01/2012
- Academic Unit
- Pathology
- Record Identifier
- 9984046805402771
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