Distinct mechanisms for processing spatial sequences and pitch sequences in the human auditory brain

J D Warren; T D Griffiths

doi:10.1523/jneurosci.23-13-05799.2003

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Distinct mechanisms for processing spatial sequences and pitch sequences in the human auditory brain

Journal article

Open access

Peer reviewed

Distinct mechanisms for processing spatial sequences and pitch sequences in the human auditory brain

J D Warren and T D Griffiths

The Journal of neuroscience, Vol.23(13), pp.5799-5804

07/02/2003

DOI: 10.1523/jneurosci.23-13-05799.2003

PMCID: PMC6741275

PMID: 12843284

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Abstract

Perception of the acoustic world requires the simultaneous processing of the acoustic patterns associated with sound objects and their location in space. In this functional magnetic resonance experiment, we investigated the human brain areas engaged in the analysis of pitch sequences and sequences of acoustic spatial locations in a paradigm in which both could be varied independently. Subjects were presented with sequences of sounds in which the individual sounds were regular interval noises with variable pitch. Positions of individual sounds were varied using a virtual acoustic space paradigm during scanning. Sound sequences with changing pitch specifically activated lateral Heschl's gyrus (HG), anterior planum temporale (PT), planum polare, and superior temporal gyrus anterior to HG. Sound sequences with changing spatial locations specifically activated posteromedial PT. These results demonstrate directly that distinct mechanisms for the analysis of pitch sequences and acoustic spatial sequences exist in the human brain. This functional differentiation is evident as early as PT: within PT, pitch pattern is processed anterolaterally and spatial location is processed posteromedially. These areas may represent human homologs of macaque lateral and medial belt, respectively.

Acoustic Stimulation - methods

Adult

Auditory Cortex - anatomy & histology

Auditory Cortex - physiology

Auditory Pathways - anatomy & histology

Auditory Pathways - physiology

Brain - anatomy & histology

Brain - physiology

Brain Mapping

Female

Humans

Magnetic Resonance Imaging

Male

Noise

Pitch Perception - physiology

Reference Values

Sound Localization - physiology

Details

Title: Subtitle: Distinct mechanisms for processing spatial sequences and pitch sequences in the human auditory brain
Creators: J D Warren - Newcastle University
T D Griffiths - Newcastle University
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.23(13), pp.5799-5804
DOI: 10.1523/jneurosci.23-13-05799.2003
PMID: 12843284
PMCID: PMC6741275
ISSN: 0270-6474
eISSN: 1529-2401
Language: English
Date published: 07/02/2003
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984627191602771

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