Journal article
Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation
Nature communications, Vol.15(1), 5968
07/16/2024
DOI: 10.1038/s41467-024-50112-7
PMCID: PMC11252339
PMID: 39013846
Abstract
Reorientation, the process of regaining one’s bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of facing direction within that context (heading retrieval). We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that male mice learn to combine both featural and geometric cues to recover heading. At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells remaps coherently in a context-sensitive manner, which serves to predict context. Efficient heading retrieval and context recognition correlate with rate changes reflecting integration of featural and geometric information in the active ensemble. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience.
Geometry is crucial in spatial reorientation, but the underlying neural mechanisms of spatial reorientation are unclear. Here, the authors show that in a two-context reorientation task, distinct CA1 cells code heading retrieval and context recognition during reorientation.
Details
- Title: Subtitle
- Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation
- Creators
- Celia M. Gagliardi - Iowa City, IA 52245 USAMarc E. Normandin - Iowa City, IA 52245 USAAlexandra T. Keinath - University of Illinois at ChicagoJoshua B. Julian - Princeton UniversityMatthew R. Lopez - University of IowaManuel-Miguel Ramos-Alvarez - Universidad de JaénRussell A. Epstein - University of PennsylvaniaIsabel A. Muzzio - Iowa City, IA 52245 USA
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.15(1), 5968
- Publisher
- Nature Publishing Group UK
- DOI
- 10.1038/s41467-024-50112-7
- PMID
- 39013846
- PMCID
- PMC11252339
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 07/16/2024
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984658254102771
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