Journal article
Distinct neurochemical influences on fMRI response polarity in the striatum
Nature communications, Vol.15(1), 1916
03/01/2024
DOI: 10.1038/s41467-024-46088-z
PMCID: PMC10907631
PMID: 38429266
Abstract
The striatum, known as the input nucleus of the basal ganglia, is extensively studied for its diverse behavioral roles. However, the relationship between its neuronal and vascular activity, vital for interpreting functional magnetic resonance imaging (fMRI) signals, has not received comprehensive examination within the striatum. Here, we demonstrate that optogenetic stimulation of dorsal striatal neurons or their afferents from various cortical and subcortical regions induces negative striatal fMRI responses in rats, manifesting as vasoconstriction. These responses occur even with heightened striatal neuronal activity, confirmed by electrophysiology and fiber-photometry. In parallel, midbrain dopaminergic neuron optogenetic modulation, coupled with electrochemical measurements, establishes a link between striatal vasodilation and dopamine release. Intriguingly, in vivo intra-striatal pharmacological manipulations during optogenetic stimulation highlight a critical role of opioidergic signaling in generating striatal vasoconstriction. This observation is substantiated by detecting striatal vasoconstriction in brain slices after synthetic opioid application. In humans, manipulations aimed at increasing striatal neuronal activity likewise elicit negative striatal fMRI responses. Our results emphasize the necessity of considering vasoactive neurotransmission alongside neuronal activity when interpreting fMRI signal.
Details
- Title: Subtitle
- Distinct neurochemical influences on fMRI response polarity in the striatum
- Creators
- Domenic H Cerri - University of North Carolina at Chapel HillDaniel L Albaugh - University of North Carolina at Chapel HillLindsay R Walton - University of North Carolina at Chapel HillBrittany Katz - University of North Carolina at Chapel HillTzu-Wen Wang - University of North Carolina at Chapel HillTzu-Hao Harry Chao - University of North Carolina at Chapel HillWeiting Zhang - University of North Carolina at Chapel HillRandal J Nonneman - University of North Carolina at Chapel HillJing Jiang - University of IowaSung-Ho Lee - University of North Carolina at Chapel HillAmit Etkin - Alto Neuroscience (United States)Catherine N Hall - University of SussexGarret D Stuber - University of WashingtonYen-Yu Ian Shih - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.15(1), 1916
- DOI
- 10.1038/s41467-024-46088-z
- PMID
- 38429266
- PMCID
- PMC10907631
- NLM abbreviation
- Nat Commun
- eISSN
- 2041-1723
- Grant note
- F32MH115439 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) T32AA007573 / U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) DP1MH116406 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P50HD103573 / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P60AA011605 / U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) U01AA020023 / U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Language
- English
- Date published
- 03/01/2024
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984562759202771
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