Journal article
Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder
Brain imaging and behavior, Vol.16(2), pp.820-833
10/02/2021
DOI: 10.1007/s11682-021-00552-2
PMCID: PMC8975910
PMID: 34601647
Abstract
Despite the high risk for suicide, relatively few studies have explored the relationship between suicide and brain imaging measures in bipolar disorder. In addition, fewer studies have explored the possibility that altered brain metabolism may be associated with suicide attempt. To begin to fill in these gaps, we evaluated functional (task based fMRI) and metabolic (quantitative T1ρ) differences associated with suicide attempt in participants with bipolar disorder. Thirty-nine participants with bipolar disorder underwent fMRI during a flashing checkerboard task and 27 also underwent quantitative T1ρ. The relationship between neuroimaging and history of suicide attempt was tested using multiple regression while adjusting for age, sex, and current mood state. Differences between two measures of suicide attempt (binary: yes/no and continuous: number of attempts) were quantified using the corrected Akaike Information Criterion. Participants who had attempted suicide had greater fMRI task-related activation in visual areas and the cerebellum. The number of suicide attempts was associated with a difference in BOLD response in the amygdala, prefrontal cortex, and cerebellum. Increased quantitative T1ρ was associated with number of suicide attempts in limbic, basal ganglia, and prefrontal cortex regions. This study is a secondary analysis with a modest sample size. Differences between measures of suicide history may be due to differences in statistical power. History of suicide was associated with limbic, prefrontal, and cerebellar alterations. Results comparing those with and without suicide attempts differed from results using number of suicide attempts, suggesting that these variables have different neurobiological underpinnings.
Details
- Title: Subtitle
- Distinct patterns of altered quantitative T1ρ and functional BOLD response associated with history of suicide attempts in bipolar disorder
- Creators
- Joseph J Shaffer - University of IowaVirginia Willour - University of IowaJess G Fiedorowicz - University of OttawaGary E Christensen - University of IowaJeffrey D Long - University of IowaCasey P Johnson - University of IowaSamantha L Schmitz - University of IowaAislinn J Williams - University of IowaJohn Wemmie - University of IowaVincent A Magnotta - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Brain imaging and behavior, Vol.16(2), pp.820-833
- DOI
- 10.1007/s11682-021-00552-2
- PMID
- 34601647
- PMCID
- PMC8975910
- NLM abbreviation
- Brain Imaging Behav
- ISSN
- 1931-7557
- eISSN
- 1931-7565
- Grant note
- name: Roger Koch; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01MH111578, U54TR001013; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: Merit Award; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: 5R01MH085724, K23MH083695; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01HL113863, P01HL014388; DOI: 10.13039/100009670, name: National Alliance for Research on Schizophrenia and Depression, award: Independent Investigator, Young Investigator Award, Independent Investigator
- Language
- English
- Date published
- 10/02/2021
- Academic Unit
- Electrical and Computer Engineering; Psychiatry; Biostatistics; Radiation Research Laboratory; Advanced Pulmonary Physiomic Imaging Laboratory; Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Neurosurgery; Holden Comprehensive Cancer Center
- Record Identifier
- 9984196962802771
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