Distinct patterns of emergence and fading of K103N and Y181C in women with subtype A vs. D after single-dose nevirapine: HIVNET 012

Susan H Eshleman; Laura A Guay; Jing Wang; Anthony Mwatha; Elizabeth R Brown; Philippa Musoke; Francis Mmiro; J Brooks Jackson

doi:10.1097/01.qai.0000174656.71276.d6

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Distinct patterns of emergence and fading of K103N and Y181C in women with subtype A vs. D after single-dose nevirapine: HIVNET 012

Journal article

Peer reviewed

Distinct patterns of emergence and fading of K103N and Y181C in women with subtype A vs. D after single-dose nevirapine: HIVNET 012

Susan H Eshleman, Laura A Guay, Jing Wang, Anthony Mwatha, Elizabeth R Brown, Philippa Musoke, Francis Mmiro and J Brooks Jackson

Journal of acquired immune deficiency syndromes (1999), Vol.40(1), pp.24-29

09/01/2005

DOI: 10.1097/01.qai.0000174656.71276.d6

PMID: 16123677

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Abstract

The HIVNET 012 trial in Uganda demonstrated that single-dose nevirapine (NVP) can prevent HIV-1 mother-to-child transmission. NVP resistance (NVPR) mutations were detected in 25% of women 6 to 8 weeks after NVP, with a higher rate of NVPR in women with subtype D than A. This study examined emergence and fading of specific NVPR mutations in women with these subtypes. Plasma HIV-1 was analyzed with the ViroSeq genotyping system (Celera Diagnostics, Alameda, CA). Genotypes were obtained from paired samples collected 7 days and 6 to 8 weeks after NVP from 140 women, 83 with subtype A and 57 with subtype D. The rate of NVPR was similar in women with subtype A vs. D at 7 days but was higher in subtype D than A at 6 to 8 weeks. The higher rate of NVPR in subtype D was explained by at least 2 factors: Y181C faded from detection at a greater rate in women with subtype A (odds ratio = 3.06; 95% CI, 1.04, 8.90) and K103N accumulated at a greater rate in women with subtype D (odds ratio = 1.74; 95% CI, 0.62, 4.87). HIV-1 subtype influences selection and fading of HIV-1 variants with specific drug resistance mutations after antiretroviral drug exposure.

Anti-HIV Agents - pharmacology

HIV-1 - drug effects

HIV Infections - virology

Humans

Molecular Sequence Data

Genes, pol - genetics

Phylogeny

HIV-1 - genetics

Anti-HIV Agents - administration & dosage

Nevirapine - pharmacology

Drug Resistance, Viral - genetics

Drug Resistance, Viral - drug effects

Female

HIV Infections - drug therapy

Nevirapine - administration & dosage

Details

Title: Subtitle: Distinct patterns of emergence and fading of K103N and Y181C in women with subtype A vs. D after single-dose nevirapine: HIVNET 012
Creators: Susan H Eshleman - The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. seshlem@jhmi.edu
Laura A Guay
Jing Wang
Anthony Mwatha
Elizabeth R Brown
Philippa Musoke
Francis Mmiro
J Brooks Jackson
Resource Type: Journal article
Publication Details: Journal of acquired immune deficiency syndromes (1999), Vol.40(1), pp.24-29
Publisher: United States
DOI: 10.1097/01.qai.0000174656.71276.d6
PMID: 16123677
ISSN: 1525-4135
eISSN: 1944-7884
Grant note: N01-AI-35173 / NIAID NIH HHS U01-AI-48054 / NIAID NIH HHS N01-AI-35173-417 / NIAID NIH HHS N01-AI-45200 / NIAID NIH HHS U01-AI-38858 / NIAID NIH HHS U01-AI-46745 / NIAID NIH HHS R01-HD042965-01 / NICHD NIH HHS
Language: English
Date published: 09/01/2005
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984046819402771

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