Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression

Michael Koenigs; Edward D Huey; Matthew Calamia; Vanessa Raymont; Daniel Tranel; Jordan Grafman

doi:10.1523/jneurosci.2324-08.2008

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Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression

Journal article

Open access

Peer reviewed

Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression

Michael Koenigs, Edward D Huey, Matthew Calamia, Vanessa Raymont, Daniel Tranel and Jordan Grafman

The Journal of neuroscience, Vol.28(47), pp.12341-12348

11/19/2008

DOI: 10.1523/jneurosci.2324-08.2008

PMCID: PMC2644261

PMID: 19020027

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Abstract

The neuroanatomical correlates of depression remain unclear. Functional imaging data have associated depression with abnormal patterns of activity in prefrontal cortex (PFC), including the ventromedial (vmPFC) and dorsolateral (dlPFC) sectors. If vmPFC and dlPFC are critical neural substrates for the pathogenesis of depression, then damage to either area should affect the expression of depressive symptoms. Using patients with brain lesions we show that, relative to nonfrontal lesions, bilateral vmPFC lesions are associated with markedly low levels of depression, whereas bilateral dorsal PFC lesions (involving dorsomedial and dorsolateral areas in both hemispheres) are associated with substantially higher levels of depression. These findings demonstrate that vmPFC and dorsal PFC are critically and causally involved in depression, although with very different roles: vmPFC damage confers resistance to depression, whereas dorsal PFC damage confers vulnerability.

Severity of Illness Index

Depression - pathology

Movement Disorders - pathology

Veterans

Humans

Middle Aged

Cognition Disorders - pathology

Tomography, X-Ray Computed - methods

Brain Injuries - complications

Male

Prefrontal Cortex - pathology

Depression - etiology

Movement Disorders - complications

Magnetic Resonance Imaging

Cognition Disorders - complications

Brain Mapping

Adult

Depression - complications

Female

Functional Laterality - physiology

Brain Injuries - pathology

Details

Title: Subtitle: Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression
Creators: Michael Koenigs - Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA
Edward D Huey
Matthew Calamia
Vanessa Raymont
Daniel Tranel
Jordan Grafman
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.28(47), pp.12341-12348
DOI: 10.1523/jneurosci.2324-08.2008
PMID: 19020027
PMCID: PMC2644261
NLM abbreviation: J Neurosci
ISSN: 1529-2401
eISSN: 1529-2401
Publisher: United States
Grant note: R01 DA022549-03 / NIDA NIH HHS Z99 NS999999 / Intramural NIH HHS P01 NS19632 / NINDS NIH HHS R01 DA022549 / NIDA NIH HHS P01 NS019632-180003 / NINDS NIH HHS P01 NS019632 / NINDS NIH HHS Z01 NS002792-19 / Intramural NIH HHS
Language: English
Date published: 11/19/2008
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002322202771

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