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Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells
Journal article   Open access   Peer reviewed

Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells

Nicole M Chapman, Mahmood Y Bilal, Noemi Cruz-Orcutt, Cory Knudson, Sofia Madinaveitia, Jonathan Light and Jon C.D Houtman
Cellular signalling, Vol.25(3), pp.639-650
03/2013
DOI: 10.1016/j.cellsig.2012.11.026
PMCID: PMC3883577
PMID: 23219913
url
https://doi.org/10.1016/j.cellsig.2012.11.026View
Published (Version of record) Open Access

Abstract

Toll-like receptor 2 (TLR2) serves as a co-stimulatory receptor for human T cells by enhancing T cell receptor (TCR)-induced cytokine production and proliferation. However, it is unknown where signals from the TCR and TLR2 converge to enhance T cell activation. To address this gap, we examined changes in TCR-induced signaling following concurrent TLR2 activation in human T cells. Both proximal TCR-mediated signaling and early NFκB activation were not enhanced by TCR andTLR2 co-activation, potentially due to the association of TLR2 with TLR10. Instead, TLR2 co-induction did augment Akt and Erk1/Erk2 activation in human T cells. These findings demonstrate that TLR2 activates distinct signaling pathways in human T cells and suggest that alterations in expression of TLR2 co-receptors may contribute to aberrant T cell responses. ► TLR2 enhances TCR activation that regulates downstream effector functions. ► Where TCR and TLR2-induced signals converge to augment T cell activation is unknown. ► TLR2 augments Akt and Erk1/Erk2 function, but not NFκB activity, in human T cells. ► TLR2 utilizes distinct signaling pathways in human T cells versus mouse T cells.
 T cell receptor signaling TLR2 co-stimulation NFκB Akt and Erk1/Erk2 Human T cells

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