Distress-Based Gastrointestinal Symptom Clusters and Impact on Symptom Interference and Quality of Life in Patients with a Hematologic Malignancy Receiving Chemotherapy

Catherine H Cherwin; Yelena Perkhounkova

doi:10.1016/j.jpainsymman.2016.11.005

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Distress-Based Gastrointestinal Symptom Clusters and Impact on Symptom Interference and Quality of Life in Patients with a Hematologic Malignancy Receiving Chemotherapy

Journal article

Open access

Peer reviewed

Distress-Based Gastrointestinal Symptom Clusters and Impact on Symptom Interference and Quality of Life in Patients with a Hematologic Malignancy Receiving Chemotherapy

Catherine H Cherwin and Yelena Perkhounkova

Journal of pain and symptom management, Vol.53(4), pp.751-758

04/2017

DOI: 10.1016/j.jpainsymman.2016.11.005

PMID: 28042061

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Abstract

People with cancer can experience co-occurring related symptoms, labeled symptom clusters. Gastrointestinal (GI) symptoms are common side effects of chemotherapy, but little research has investigated GI symptom clusters. A further gap in symptom cluster research is the lack of studies reporting symptom clusters based on symptom distress ratings. To identify distress-based GI symptom clusters and to investigate their relationship to symptom interference with daily life and quality of life (QoL). About 105 adults with hematologic malignancy receiving chemotherapy. On Day 1 of a cycle of chemotherapy, participants completed a modified version of the Memorial Symptom Assessment Scale assessing 30 clinically relevant symptoms, the M.D. Anderson Symptom Inventory Symptom Interference with Daily Life subscale, and the Fox Simple Quality of Life Scale. Exploratory factor analysis was used to identify distress-based symptom clusters. Symptom clusters with ≥50% GI symptoms were labeled GI symptom clusters. Linear mixed modeling explored relationships between GI symptom clusters and symptom interference with daily life and QoL. Of the six distress-based symptom clusters found, the bloating cluster and appetite cluster were identified as GI symptom clusters. Both the bloating cluster and the appetite cluster were significantly related to symptom interference with daily life, but only the appetite cluster was significantly related to QoL. This research demonstrates the existence of distress-based GI symptom clusters and their relationship to symptom interference and QoL. Future work should explore predictors of distress-based symptom clusters and interventions to manage them.

Gastrointestinal Diseases - physiopathology

Humans

Middle Aged

Gastrointestinal Diseases - etiology

Male

Antineoplastic Agents - therapeutic use

Activities of Daily Living

Young Adult

Antineoplastic Agents - adverse effects

Aged, 80 and over

Adult

Female

Hematologic Neoplasms - complications

Hematologic Neoplasms - physiopathology

Gastrointestinal Diseases - psychology

Linear Models

Factor Analysis, Statistical

Syndrome

Hematologic Neoplasms - psychology

Adolescent

Hematologic Neoplasms - drug therapy

Quality of Life

Aged

Stress, Psychological - etiology

Stress, Psychological - physiopathology

Details

Title: Subtitle: Distress-Based Gastrointestinal Symptom Clusters and Impact on Symptom Interference and Quality of Life in Patients with a Hematologic Malignancy Receiving Chemotherapy
Creators: Catherine H Cherwin - University of Iowa College of Nursing, Iowa City, Iowa, USA. Electronic address: catherine-cherwin@uiowa.edu
Yelena Perkhounkova - University of Iowa College of Nursing, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Journal of pain and symptom management, Vol.53(4), pp.751-758
DOI: 10.1016/j.jpainsymman.2016.11.005
PMID: 28042061
NLM abbreviation: J Pain Symptom Manage
ISSN: 0885-3924
eISSN: 1873-6513
Publisher: United States
Grant note: T32 NR007102 / NINR NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Nursing
Record Identifier: 9984064277702771

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