Distress and expression of natural killer receptors on lymphocytes

Susan K Lutgendorf; Mikel B Moore; Sarah Bradley; Brent J Shelton; Charles T Lutz

doi:10.1016/j.bbi.2004.11.003

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Distress and expression of natural killer receptors on lymphocytes

Journal article

Peer reviewed

Distress and expression of natural killer receptors on lymphocytes

Susan K Lutgendorf, Mikel B Moore, Sarah Bradley, Brent J Shelton and Charles T Lutz

Brain, behavior, and immunity, Vol.19(3), pp.185-194

2005

DOI: 10.1016/j.bbi.2004.11.003

PMID: 15797305

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Abstract

Chronic distress has been associated with alterations in natural killer (NK) cell and T cell percentages and function. NK cells express inhibitory and stimulatory receptors that regulate cytotoxicity and cytokine secretion. T cells and T cells expressing CD56 (NKT cells) also express these NK-associated receptors, which are thought to serve the same function. The objective of this study was to examine the relationship between distress and expression of NK-associated receptors on NK cells, T cells, and NKT cells. Using multicolor flow cytometry and validated questionnaires, we studied twenty-nine healthy adults with a bimodal age spread. Whereas distress was related to significantly lower percentages of CD3 + T cells, it was related to significantly higher percentages of NKT cells. Distress was associated with significantly higher percentages of T cells expressing NK-associated receptors including CD94 and KIR. In contrast, distress was associated with significantly lower percentages of NK cells bearing KIR (GL183) receptors. Our findings suggest a possible role for NK-associated receptors in distress-related alterations in lymphocyte maturation, trafficking, or activity.

Distress

Psychoneuroimmunology

Natural killer receptors

NKT cells

Kiribati

Stress

Details

Title: Subtitle: Distress and expression of natural killer receptors on lymphocytes
Creators: Susan K Lutgendorf - Department of Psychology and Department of Obstetrics and Gynecology, University of Iowa, USA
Mikel B Moore - Department of Pathology and Laboratory Medicine and Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, USA
Sarah Bradley - College of Medicine, University of Iowa, USA
Brent J Shelton - Department of Internal Medicine and Department of Biostatistics, University of Kentucky Colleges of Medicine and Public Health, USA
Charles T Lutz - Department of Pathology and Laboratory Medicine and Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, USA
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.19(3), pp.185-194
DOI: 10.1016/j.bbi.2004.11.003
PMID: 15797305
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Language: English
Date published: 2005
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065883102771

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