Journal article
Distribution of Dystroglycan in Normal Adult Mouse Tissues
The journal of histochemistry and cytochemistry, Vol.46(4), pp.449-457
04/1998
DOI: 10.1177/002215549804600404
PMID: 9524190
Abstract
Dystroglycan is a cell surface protein which, in muscle, links the extracellular matrix protein laminin-2 to the intracellular cytoskeleton. Dystroglycan also binds laminin-1 and the binding occurs via the E3 fragment of laminin-1. Recently, it was found that dystroglycan is expressed in developing epithelial cells of the kidney. Moreover, antibodies against dystroglycan can perturb epithelial development in kidney organ culture. Therefore, dystroglycan may be an important receptor for cell-matrix interactions in non-muscle tissues. However, information about the tissue distribution of dystroglycan is limited, especially in adult tissues. Here we show that dystroglycan is present in epithelial cells in several non-muscle organs of adult mice. Dystroglycan is enriched towards the basal side of the epithelial cells that are in close contact with basement membranes. We suggest that dystroglycan is involved in linking basement membranes to epithelial and muscle cells. Dystroglycan may be important for the maintenance of tissue integrity.
Details
- Title: Subtitle
- Distribution of Dystroglycan in Normal Adult Mouse Tissues
- Creators
- Madeleine Durbeej - Department of Animal Physiology, Uppsala University, Uppsala, Sweden, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IowaMichael D Henry - Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IowaMaria Ferletta - Department of Animal Physiology, Uppsala University, Uppsala, SwedenKevin P Campbell - Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IowaPeter Ekblom - Department of Animal Physiology, Uppsala University, Uppsala, Sweden
- Resource Type
- Journal article
- Publication Details
- The journal of histochemistry and cytochemistry, Vol.46(4), pp.449-457
- DOI
- 10.1177/002215549804600404
- PMID
- 9524190
- NLM abbreviation
- J Histochem Cytochem
- ISSN
- 0022-1554
- eISSN
- 1551-5044
- Language
- English
- Date published
- 04/1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology; Internal Medicine
- Record Identifier
- 9984068274802771
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