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Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes
Journal article   Peer reviewed

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

Neal G Copeland, Debra J Gilbert, Chris Schindler, Zhong Zhong, Zilong Wen, James E Darnell, Alice L.-F Mui, Atsushi Miyajima, Frederick W Quelle, James N Ihle, …
Genomics (San Diego, Calif.), Vol.29(1), pp.225-228
1995
DOI: 10.1006/geno.1995.1235
PMID: 8530075

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Abstract

Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.

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