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Divergence of TORC1-mediated stress response leads to novel acquired stress resistance in a pathogenic yeast
Journal article   Open access   Peer reviewed

Divergence of TORC1-mediated stress response leads to novel acquired stress resistance in a pathogenic yeast

Jinye Liang, Hanxi Tang, Lindsey F. Snyder, Christopher E. Youngstrom and Bin Z. He
PLoS pathogens, Vol.19(10), e1011748
10/23/2023
DOI: 10.1371/journal.ppat.1011748
PMCID: PMC10621968
PMID: 37871123
url
https://doi.org/10.1371/journal.ppat.1011748View
Published (Version of record) Open Access

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Abstract

Acquired stress resistance (ASR) enables organisms to prepare for environmental changes that occur after an initial stressor. However, the genetic basis for ASR and how the underlying network evolved remain poorly understood. In this study, we discovered that a short phosphate starvation induces oxidative stress response (OSR) genes in the pathogenic yeast C . glabrata and protects it against a severe H 2 O 2 stress; the same treatment, however, provides little benefit in the low pathogenic-potential relative, S . cerevisiae . This ASR involves the same transcription factors (TFs) as the OSR, but with different combinatorial logics. We show that Target-of-Rapamycin Complex 1 (TORC1) is differentially inhibited by phosphate starvation in the two species and contributes to the ASR via its proximal effector, Sch9. Therefore, evolution of the phosphate starvation-induced ASR involves the rewiring of TORC1’s response to phosphate limitation and the repurposing of TF-target gene networks for the OSR using new regulatory logics.

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